892742-76-6
Chemical Structure
UT-B-IN-1
- CAS No.: 892742-76-6
- Formula:C20H17N5O2S3
- Molecular Weight:455.58
IUPAC Name: 3-((4-ethylphenyl)sulfonyl)-N-(thiophen-2-ylmethyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
InChIKey: UYFZCWXRMHSLTC-UHFFFAOYSA-N
SMILES: O=S(C1=C2N=C(NCC3=CC=CS3)C4=C(C=CS4)N2N=N1)(C5=CC=C(CC)C=C5)=O
Biological Activity: UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
UT-B-IN-1 | 98.07% | UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
