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Results for "

Wdr5-MLL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) HDAC (1) WDR5 (9)
By Research Areas:	Cancer (8)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12220A

MM-102 TFA 4 Publications Verification HMTase Inhibitor IX TFA	WDR5	Cancer
MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM with an estimated Ki < 1 nM in WDR5 binding assay, which is >200 times more potent than the ARA peptide.

HY-16994

OICR-0547	WDR5	Cancer
OICR-0547 is a negative control, closely related derivative of OICR-9429 (HY-16993). OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction. OICR-0547 is an inactive control compound that no longer binds to WDR5 .

HY-153331

DDO-2213	WDR5	Cancer
DDO-2213 is an orally active and potent *WDR5-MLL1* inhibitor, with an IC₅₀ of 29 nM and a K_d value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research .

HY-157659

WDR5-47	WDR5	Others
WDR5-MLL1 antagonist 1 (compound 47) is a compound optimized through protein crystal structure guidance. It has stronger antagonistic activity against WDR5-MLL interaction with a dissociation constant (Kd) of 0.3μM.

HY-148817

WDR5-0102	WDR5	Cancer
WDR5-0102 is an inhibitor of *WDR5. WDR5-0102 specifically targets the WIN* site of *WDR5, disrupts the WDR5-MLL1* interaction, and reduces the histone methyltransferase activity of MLL1. WDR5-0102 exerts dose-dependent toxicity on MDSC-like cells and reduces their osteopontin levels, while showing extremely low cytotoxicity to pancreatic cancer cells. WDR5-0102 can be used in the research of related diseases such as acute myeloid leukemia, lymphoid leukemia, biphenotypic leukemia and pancreatic cancer .

HY-178751

Z116334910	WDR5	Cancer
Z116334910 is a promising *WDR5-MLL1* interaction disruptor. Z116334910 can be used for the study of cancer .

HY-178752

Z88418521	WDR5	Cancer
Z88418521 is a ligand for the *WDR5-MLL1* complex. Z88418521 may help disrupt the interaction of the *WDR5-MLL1* complex. Z88418521 can be used in cancer research, especially in leukemia .

HY-168475

DD0-2363	Apoptosis WDR5 HDAC	Cancer
DD0-2363 (Compound 32d) is a dual-target inhibitor of *WDR5-MLL1/HDAC. DD0-2363 inhibits cells proliferation and induces apoptosis* in acute myeloid leukemia cells. DD0-2363 has antitumor activity and can be used in the research of acute myeloid leukemia .

HY-183959

DC_M5_2	WDR5	Cancer
DC_M5_2 is a WD40 repeat domain protein 5 (WDR5) inhibitor with an IC₅₀ of 9.63 μM and a K_D of 13.8 μM. DC_M5_2 binds to the WDR5 pocket that interacts with the MLL1 peptide, blocking the *WDR5-MLL1* protein-protein interaction . DC_M5_2 can be used in leukemia-related research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Wdr5-MLL

Inhibitors & Agonists