1801873-49-3
1801873-49-3
Chemical Structure
OICR-0547
- CAS No.: 1801873-49-3
- Formula:C28H29F3N4O4
- Molecular Weight:542.55
IUPAC Name: N-(4-morpholino-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
InChIKey: RFHOOFYUTGZPFH-UHFFFAOYSA-N
SMILES: O=C(C1=CNC(C=C1C(F)(F)F)=O)NC2=CC(C3=CC(CN4CCOCC4)=CC=C3)=CC=C2N5CCOCC5
Biological Activity: OICR-0547 is a negative control, closely related derivative of OICR-9429 (HY-16993). OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction. OICR-0547 is an inactive control compound that no longer binds to WDR5[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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OICR-0547 | 99.85% | OICR-0547 is a negative control, closely related derivative of OICR-9429 (HY-16993). OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction. OICR-0547 is an inactive control compound that no longer binds to WDR5. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.89
HY-16993OICR-9429 -
Similarity Score 0.78
HY-141798OICR-9429-N-C2-NH2 -
Similarity Score 0.66
HY-168488WDR5 ligand 2 -
Similarity Score 0.61
HY-184594WDR5 ligand 4 -
Similarity Score 0.60
HY-141799Dimethyl-F-OICR-9429-COOH -
Similarity Score 0.52
HY-137498EBOV/MARV-IN-1 -
Similarity Score 0.52
HY-100510RAF709 -
Similarity Score 0.51
HY-13803RTazemetostat (Standard) -
Similarity Score 0.51
HY-148829MS40 -
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References
- [1]. Grebien F, et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol. 2015 Aug;11(8):571-578. [Content Brief]
- [2]. Matthäus Getlik, et al. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J Med Chem. 2016 Mar 24;59(6):2478-96. [Content Brief]
