1. MAPK/ERK Pathway
  2. Raf

RAF709 

Cat. No.: HY-100510 Purity: 99.55%
Data Sheet SDS Handling Instructions

RAF709 is a novel Raf kinase inhibitor extracted from patent WO2014151616A1, compound example 131, has an IC50 of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.

For research use only. We do not sell to patients.
RAF709 Chemical Structure

RAF709 Chemical Structure

CAS No. : 1628838-42-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO $418 In-stock
1 mg $110 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
25 mg $1000 In-stock
50 mg $1500 In-stock
100 mg $2400 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

RAF709 is a novel Raf kinase inhibitor extracted from patent WO2014151616A1, compound example 131, has an IC50 of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.

IC50 & Target

IC50: 0.5 nM (c-Raf), 1.8 nM (b-Raf)[1]

In Vitro

The invention provides compounds (e.g., RAF709) that inhibit Raf kinases, and are accordingly useful for treating certain disorders associated with excessive Raf kinase activity, including cell proliferation disorders such as cancers[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.8431 mL 9.2157 mL 18.4315 mL
5 mM 0.3686 mL 1.8431 mL 3.6863 mL
10 mM 0.1843 mL 0.9216 mL 1.8431 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

542.55

Formula

C₂₈H₂₉F₃N₄O₄

CAS No.

1628838-42-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 100 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
RAF709
Cat. No.:
HY-100510
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