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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
Whole-cell patch clamp
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "Whole-cell patch clamp" in MCE Product Catalog:
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VU591 is a selective inhibitor of the renal outer medullary potassium channel (ROMK, Kir1.1). VU591 inhibits ROMK via binding to the intracellular pore region near residues Val168 and Asn171, with IC50 of 240 nM in Tl + flux assay and 300 nM in whole cell patch clamp electrophysiology, suppresses native ROMK mediated K + secretion in isolated perfused rat collecting ducts, and exerts antidepressive effects in the mouse tail suspension test (TST). VU591 can be used for the study of ROMK channel function, renal potassium handling, antidepressant mechanisms, and diuretic drug discovery .
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VU591 hydrochloride is a selective inhibitor of the renal outer medullary potassium channel (ROMK, Kir1.1). VU591 hydrochloride inhibits ROMK via binding to the intracellular pore region near residues Val168 and Asn171, with IC50 of 240 nM in Tl + flux assay and 300 nM in whole cell patch clamp electrophysiology, suppresses native ROMK mediated K + secretion in isolated perfused rat collecting ducts, and exerts antidepressive effects in the mouse tail suspension test (TST). VU591 hydrochloride can be used for the study of ROMK channel function, renal potassium handling, antidepressant mechanisms, and diuretic drug discovery .
Cat. No.: HY-126336
CAS No.: 2376051-91-9
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HM12 is a covalent inhibitor of L-/T-type calcium channels. HM12 can strongly inhibit the Cav1.2 (L-type) and Cav3.2 (T-type) calcium channels, and has selectivity for the N-type channels. HM12 produces an irreversible inhibition that persisted after washout. HM12 can be used to study diseases such as hypertension, pain, epilepsy, etc .
Cat. No.: HY-120059
CAS No.: 273930-52-2
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NS4591 is a modulator of calcium-activated potassium channels with activity that enhances small (SK) and intermediate (IK) conductivity. NS4591 doubled IK-mediated currents in whole-cell patch-clamp experiments at a concentration of 45 +/- 6 nM, and doubled SK3-mediated currents at a concentration of 530 +/- 100 nM. NS4591 inhibits the number of action potentials generated by suprathreshold depolarizing pulses in acutely isolated bladder primary afferent neurons. NS4591 also reduced carbakol-induced detrusor ring contraction in the rat bladder, demonstrating sensitivity to apamin .
Cat. No.: HY-183056
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P2X3 antagonist 40 is a P2X3 antagonist with a human P2X3 receptor pIC50 < 4.52. P2X3 antagonist 40 can be used for research on ATP-mediated proinflammatory fingerprint, including overactive bladder, pain, and chronic cough .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
