2376051-91-9
Chemical Structure
HM12
- CAS No.: 2376051-91-9
- Formula:C25H27Br2NO6
- Molecular Weight:597.29
IUPAC Name: 2-(methacryloyloxy)ethyl 4-(3,5-dibromo-2-hydroxyphenyl)-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
InChIKey: OKTMUPRPBYWQJZ-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)NC2=C(C(C(C)(C)CC2)=O)C1C3=CC(Br)=CC(Br)=C3O)OCCOC(C(C)=C)=O
Biological Activity: HM12 is a covalent inhibitor of L-/T-type calcium channels. HM12 can strongly inhibit the Cav1.2 (L-type) and Cav3.2 (T-type) calcium channels, and has selectivity for the N-type channels. HM12 produces an irreversible inhibition that persisted after washout. HM12 can be used to study diseases such as hypertension, pain, epilepsy, etc[1].
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HM12 | HM12 is a covalent inhibitor of L-/T-type calcium channels. HM12 can strongly inhibit the Cav1.2 (L-type) and Cav3.2 (T-type) calcium channels, and has selectivity for the N-type channels. HM12 produces an irreversible inhibition that persisted after washout. HM12 can be used to study diseases such as hypertension, pain, epilepsy, etc. | |||||||||||||||||||||
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Keywords
