1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. VU591

VU591 

Cat. No.: HY-108585A Purity: 99.38%
Handling Instructions

VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM.

For research use only. We do not sell to patients.

VU591 Chemical Structure

VU591 Chemical Structure

CAS No. : 1222810-74-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 290 In-stock
Estimated Time of Arrival: December 31
50 mg USD 520 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of VU591:

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Description

VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM[1].

IC50 & Target

IC50: 0.24 μM (ROMK)[1].

Molecular Weight

368.30

Formula

C₁₆H₁₂N₆O₅

CAS No.

1222810-74-3

SMILES

C1=CC2=C(C=C1[N+](=O)[O-])NC(=N2)COCC3=NC4=C(C=C(C=C4)[N+](=O)[O-])N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (169.70 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7152 mL 13.5759 mL 27.1518 mL
5 mM 0.5430 mL 2.7152 mL 5.4304 mL
10 mM 0.2715 mL 1.3576 mL 2.7152 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.08 mg/mL (5.65 mM); Precipitated solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product name:
VU591
Cat. No.:
HY-108585A
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