273930-52-2
Chemical Structure
NS4591
- CAS No.: 273930-52-2
- Formula:C11H12Cl2N2O
- Molecular Weight:259.13
IUPAC Name: 4,5-dichloro-1,3-diethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
InChIKey: PHJOFWDUFPTPDH-UHFFFAOYSA-N
SMILES: O=C1N(C2=C(C(Cl)=CC=C2N1CC)Cl)CC
Biological Activity: NS4591 is a modulator of calcium-activated potassium channels with activity that enhances small (SK) and intermediate (IK) conductivity. NS4591 doubled IK-mediated currents in whole-cell patch-clamp experiments at a concentration of 45 +/- 6 nM, and doubled SK3-mediated currents at a concentration of 530 +/- 100 nM. NS4591 inhibits the number of action potentials generated by suprathreshold depolarizing pulses in acutely isolated bladder primary afferent neurons. NS4591 also reduced carbakol-induced detrusor ring contraction in the rat bladder, demonstrating sensitivity to apamin[1].
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NS4591 | NS4591 is a modulator of calcium-activated potassium channels with activity that enhances small (SK) and intermediate (IK) conductivity. NS4591 doubled IK-mediated currents in whole-cell patch-clamp experiments at a concentration of 45 +/- 6 nM, and doubled SK3-mediated currents at a concentration of 530 +/- 100 nM. NS4591 inhibits the number of action potentials generated by suprathreshold depolarizing pulses in acutely isolated bladder primary afferent neurons. NS4591 also reduced carbakol-induced detrusor ring contraction in the rat bladder, demonstrating sensitivity to apamin. | |||||||||||||||||||||
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