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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
Z-DNA
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "Z-DNA" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-P71436
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ZBP1; Z‑DNA Binding Protein 1; alias:C20orf183; DLM1; DAI; Tumor Stroma And Activated Macrophage Protein DLM‑1; Z‑DNA‑Binding Protein 1; DLM‑1; DNA‑Dependent Activator Of IRFs; DJ718J7.3; DNA‑Dependent Activator Of IFN‑Regulatory Factors; Chromosome 20 Op
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Guanosine, 8-methyl-2′-O-methyl-
Synonyms: m8Gm
Cat. No.: HY-121473
CAS No.: 60504-57-6
Target:
Research Areas:
Aklavin is a structural analog of Aclacinomycin A (HY-N2306) produced by Streptomyces strain A 1165. Aklavin possesses Z-DNA-inducing and stabilizing activities, along with antibiotic, anti-phage and broad-spectrum antimicrobial activities. Aklavin inhibits the proliferation of various viruses (such as influenza virus and poliovirus) and interferes with their nucleoprotein synthesis, while also exhibiting inhibitory effects on staphylococci, mycobacteria and specific fungi. Aklavin blocks phage-induced bacterial lysis by regulating host-parasite interactions. Aklavin shows specific toxicity to fertilized eggs and mice, and does not alter the splicing of the SMN2 gene .
Cat. No.: HY-P704188
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ZBP1; Z‑DNA Binding Protein 1; alias:C20orf183; DLM1; DAI; Tumor Stroma And Activated Macrophage Protein DLM‑1; Z‑DNA‑Binding Protein 1; DLM‑1; DNA‑Dependent Activator Of IRFs; DJ718J7.3; DNA‑Dependent Activator Of IFN‑Regulatory Factors; Chromosome 20 Op
Cat. No.: HY-P704184
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ZBP1; Z‑DNA Binding Protein 1; alias:C20orf183; DLM1; DAI; Tumor Stroma And Activated Macrophage Protein DLM‑1; Z‑DNA‑Binding Protein 1; DLM‑1; DNA‑Dependent Activator Of IRFs; DJ718J7.3; DNA‑Dependent Activator Of IFN‑Regulatory Factors; Chromosome 20 Op
Cat. No.: HY-185102
Research Areas:
ZBP1 PROTAC-1 is a Z-DNA-binding protein 1 (ZBP1) PROTAC degrader with a DC50 of 25.69 nM. ZBP1 PROTAC-1 consists of a DNA aptamer that specifically binds to ZBP1 and an E3 enzyme-recruiting moiety. ZBP1 PROTAC-1 combines the specificity and covalent binding ability of DNA aptamers with the PROTAC-mediated degradation function. By degrading ZBP1, ZBP1 PROTAC-1 inhibits the phosphorylation of RIPK3/MLKL to necrotic apoptosis and reduces the levels of proinflammatory cytokines (IL-18, IL-1β, IL-6, TNF-α, IFN-β). ZBP1 PROTAC-1 can be used in the research of viral pneumonia and influenza A H1N1 virus infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
