2306782-64-7
2306782-64-7
Chemical Structure
2′-O-Methyl-8-methyl guanosine
Synonym(s): m8Gm
- CAS No.: 2306782-64-7
- Formula:C12H17N5O5
- Molecular Weight:311.29
IUPAC Name: 2-amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-8-methyl-3,9-dihydro-6H-purin-6-one
InChIKey: VKBDRYNPOJCCAX-IOSLPCCCSA-N
SMILES: O[C@H]1[C@@H](OC)[C@H](N2C(NC(N)=NC3=O)=C3N=C2C)O[C@@H]1CO
Biological Activity: 2′-O-Methyl-8-methyl guanosine (m8Gm) is a Z-form RNA stabilizer. 2′-O-Methyl-8-methyl guanosine can markedly stabilize the Z-RNA at low salt conditions[1]. m8Gm-contained oligonucleotides stabilize the Z-DNA under low salt conditions[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2′-O-Methyl-8-methyl guanosine | 98.04% | 2′-O-Methyl-8-methyl guanosine (m8Gm) is a Z-form RNA stabilizer. 2′-O-Methyl-8-methyl guanosine can markedly stabilize the Z-RNA at low salt conditions. m8Gm-contained oligonucleotides stabilize the Z-DNA under low salt conditions. | ||||||||||||||||||||
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References
- [1]. Balasubramaniyam T, Ishizuka T, Xiao CD, Bao HL, Xu Y. 2'-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA. Molecules. 2018;23(10):2572. [Content Brief]
- [2]. Balasubramaniyam T, Ishizuka T, Xu Y. Stability and properties of Z-DNA containing artificial nucleobase 2'-O-methyl-8-methyl guanosine. Bioorg Med Chem. 2019;27(2):364-369. [Content Brief]
Keywords
