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disubstituted

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By Targets:	ADC Payload (1) Apoptosis (3) Bacterial (3) Biochemical Assay Reagents (13) Drug Intermediate (2) EGFR (2) GABA Receptor (1) Glutathione S-transferase (2) HIV (1) Integrin (1) Keap1-Nrf2 (1) P-glycoprotein (1) Parasite (1) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) SARS-CoV (1) Sirtuin (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (2)
Click Chemistry:	ADC Synthesis (1) Azide (1)

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Biochemical Assay Reagents

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13306

Pyrintegrin 4 Publications Verification	Integrin	Metabolic Disease
Pyrintegrin is an β1-integrin agonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediated integrin signaling. Pyrintegrin can be used as a podocyte-protective agent and has robustly adipogenic .

HY-N0548

α-Angelica lactone 2 Publications Verification	Glutathione S-transferase	Cancer
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-116152

Cipepofol Ciprofol; HSK3486	GABA Receptor Sirtuin Keap1-Nrf2 Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABA_A receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis .

HY-116544

Octan-2-yl 2-cyanoacrylate	Biochemical Assay Reagents	Others
Octan-2-yl 2-cyanoacrylate is an alkyl cyanoacrylate monomer, base-sensitive monofunctional 1,1-disubstituted electron-deficient olefin, polymerizable and copolymerizable monomer. Octan-2-yl 2-cyanoacrylate undergoes homopolymerization via nucleophilic initiation with pyridine as initiator. Octan-2-yl 2-cyanoacrylate forms true copolymers with ethyl 2-cyanoacrylate via nucleophilic initiation with pyridine as initiator .

HY-145149

Duostatin 5	ADC Payload	Cancer
Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].

HY-W003486

5,7-Dichloropyrazolo[1,5-a]pyrimidine	Phosphodiesterase (PDE)	Neurological Disease Cancer
5,7-Dichloropyrazolo[1,5-a]pyrimidine is a PDE10A inhibitor with a K_i of 24 μM. 5,7-Dichloropyrazolo[1,5-a]pyrimidine serves as a key intermediate in the synthesis of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives (HIV-1 non-nucleoside reverse transcriptase inhibitors). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used for the research of schizophrenia .

HY-17499

EGFR-IN-12	EGFR Apoptosis	Cancer
EGFR-IN-12 is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC₅₀of 21 nM. EGFR-IN-12 also inhibits mutant EGFR ^L858R and EGFR ^L861Q with IC₅₀s of 63 nM and 4 nM, respectively. EGFR-IN-12 displays strong selectivity for EGFR over HER4 (IC₅₀ = 7640 nM) and a panel of 55 other kinases. EGFR-IN-12 induces cells apoptosis and has antitumor activity .

HY-N0548R

α-Angelica lactone (Standard)	Glutathione S-transferase Reference Standards	Cancer
α-Angelica lactone (Standard) is the analytical standard of α-Angelica lactone. This product is intended for research and analytical applications. α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

HY-136240

Tioxazafen	Parasite	Infection
Tioxazafen is a disubstituted oxadiazole and a broad-spectrum seed treatment nematicide. Tioxazafen is designed to provide consistent broad-spectrum control of nematodes in corn, soy, and cotton .

HY-W019738

1,1'-Dibromoferrocene	Drug Intermediate	Others
1,1'-Dibromoferrocene is a drug synthesis intermediate that can be used to synthesize a wide number of 1,2-disubstituted ferrocenes .

HY-W1120356

Bis-PEG12-NHS Ester	Biochemical Assay Reagents	Others
Bis-PEG12-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

HY-17499R

EGFR-IN-12 (Standard)	EGFR Apoptosis	Cancer
EGFR-IN-12 (Standard) is the analytical standard of EGFR-IN-12. This product is intended for research and analytical applications. EGFR-IN-12 is a 4,6-disubstituted pyrimidine and is a potent, ATP-competitive, irreversible and highly selective EGFR inhibitor with an IC50of 21 nM. EGFR-IN-12 also inhibits mutant EGFRL858R and EGFRL861Q with IC50s of 63 nM and 4 nM, respectively. EGFR-IN-12 displays strong selectivity for EGFR over HER4 (IC50 = 7640 nM) and a panel of 55 other kinases. EGFR-IN-12 induces cells apoptosis and has antitumor activity .

HY-W811579

Bensuldazic acid	Bacterial	Infection
Bensuldazic acid (compound 4f) is a lipophilic 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivative that can be used as a prodrug model. Bensuldazic acid has antifungal activity .

HY-W811579A

Bensuldazic acid sodium	Bacterial	Infection
Bensuldazic acid sodium (compound 4f) is a lipophilic 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivative that can be used as a prodrug model. Bensuldazic acid has antifungal activity .

HY-W1120356C

Bis-PEG8-NHS ester	Biochemical Assay Reagents	Others
Bis-PEG8-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

HY-W1120356B

Bis-PEG24-NHS ester	Biochemical Assay Reagents	Others
Bis-PEG24-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

HY-116918

N,N-Diphenylacetamide N-Acetyldiphenylamine	Drug Intermediate	Others
N,N-Diphenylacetamide (N-Acetyldiphenylamine) has N,N-disubstituted amide group and can be used as a mono- as well as a bidentate ligand generating four-membered chelate rings .

HY-149360

P-gb-IN-1	P-glycoprotein	Cancer
P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells .

HY-162604

SARS-CoV-2-IN-90	SARS-CoV	Infection
SARS-CoV-2-IN-90 (compound 3i) is a SARS-CoV-2 inhibitor. SARS-CoV-2-IN-90 can be used in coronavirus infection related research .

HY-106429

OT-551 free base	Reactive Oxygen Species (ROS)	Others
OT-551 (free base) is a lipophilic, disubstituted hydroxylamine with antioxidant properties. OT-551 can be used as an eye drop and can be converted by intraocular esterases to its active metabolite, Tempol-H (TP-H). OT-551 can be utilized in geographic atrophy and macular degeneration research .

HY-119202

(S)-BMS-378806 (S)-BMS-806	HIV	Infection
(S)-BMS-378806 ((S)-BMS-806) is an orally bioavailable HIV-1 inhibitor with activity against gp120-CD4 interactions. (S)-BMS-378806 exhibits micromolar inhibition of HIV-1 gp120-CD4 binding. The design and synthesis of (S)-BMS-378806 was based on a comprehensive study of protein-ligand interactions, which guided the identification and design of novel symmetrical N,N'-disubstituted aminoureas and thioureas. (S)-BMS-378806, synthesized in aqueous media using microwave irradiation, was validated for its inhibitory activity in HIV-1 gp120-CD4 capture ELISA .

HY-181177

Antibacterial agent 320	Bacterial	Infection
Antibacterial agent 320, 1,5-disubstituted 1,2,3-triazole derivative, is an antibacterial agent. Antibacterial agent 320 exerts strong antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus. Antibacterial agent 320 can be used for the research of bacterial infection .

HY-W1120356A

Bis-PEG37-NHS ester	Biochemical Assay Reagents	Others
Bis-PEG37-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

HY-E71200J

16S rRNA (guanine1405-N7)-Methyltransferase	Biochemical Assay Reagents	Others
16S rRNA (guanine1405-N7)-Methyltransferase (EC 2.1.1.179) specifically methylates guanine1405 at N7 in 16S rRNA, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins.

HY-W788246

Bis-PEG1-sulfonic acid	Biochemical Assay Reagents	Others
Bis-PEG1-sulfonic acid is a homofunctional disubstituted PEG derivative useful for drug delivery .

HY-W190751

Bis-PEG9-t-butyl ester	Biochemical Assay Reagents	Others
Bis-PEG9-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

HY-W190754

Bis-PEG13-t-butyl ester	Biochemical Assay Reagents	Others
Bis-PEG13-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

HY-W190751B

Bis-PEG12-t-butyl ester	Biochemical Assay Reagents	Others
Bis-PEG12-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

HY-W190751C

Bis-PEG33-t-butyl ester	Biochemical Assay Reagents	Others
Bis-PEG33-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

HY-W190751A

Bis-PEG11-t-butyl ester	Biochemical Assay Reagents	Others
Bis-PEG11-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

HY-174906

Bis-PEG1000-COOH	Biochemical Assay Reagents	Others
Bis-PEG1000-COOH is a disubstituted PEG derivative with the same functional group. The carboxylic acid group in Bis-PEG1000-COOH can react with other compounds containing amino, hydroxyl and other functional groups to form stable chemical bonds, which can be used for drug delivery .

1,1'-Dibromoferrocene	Biochemical Assay Reagents
1,1'-Dibromoferrocene is a drug synthesis intermediate that can be used to synthesize a wide number of 1,2-disubstituted ferrocenes .

Bis-PEG12-NHS Ester	Biochemical Assay Reagents
Bis-PEG12-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

Bis-PEG8-NHS ester	Biochemical Assay Reagents
Bis-PEG8-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

Bis-PEG24-NHS ester	Biochemical Assay Reagents
Bis-PEG24-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

Bis-PEG37-NHS ester	Biochemical Assay Reagents
Bis-PEG37-NHS Ester is a homofunctional disubstituted PEG derivative for drug delivery.

Bis-PEG1-sulfonic acid	Biochemical Assay Reagents
Bis-PEG1-sulfonic acid is a homofunctional disubstituted PEG derivative useful for drug delivery .

Bis-PEG9-t-butyl ester	Biochemical Assay Reagents
Bis-PEG9-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

Bis-PEG13-t-butyl ester	Biochemical Assay Reagents
Bis-PEG13-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

Bis-PEG12-t-butyl ester	Biochemical Assay Reagents
Bis-PEG12-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

Bis-PEG33-t-butyl ester	Biochemical Assay Reagents
Bis-PEG33-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

Bis-PEG11-t-butyl ester	Biochemical Assay Reagents
Bis-PEG11-t-butyl ester is a disubstituted PEG derivative with the same functional group and can be used for drug delivery.

Bis-PEG1000-COOH	Biochemical Assay Reagents
Bis-PEG1000-COOH is a disubstituted PEG derivative with the same functional group. The carboxylic acid group in Bis-PEG1000-COOH can react with other compounds containing amino, hydroxyl and other functional groups to form stable chemical bonds, which can be used for drug delivery .

α-Angelica lactone 2 Publications Verification	Natural Products Classification of Application Fields Dicerothamnus rhinocerotis Umbelliferae Plants Disease Research Fields Source Classification Cancer	Glutathione S-transferase
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .

Cat. No.	Product Name		Classification

HY-145149

Duostatin 5		Azide ADC Synthesis
Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].

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disubstituted

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Click Chemistry

Natural
Products