57489-77-7
![5,7-Dichloropyrazolo[1,5-a]pyrimidine Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-w003486.gif "5,7-Dichloropyrazolo[1,5-a]pyrimidine Chemical Structure")
57489-77-7
Chemical Structure
5,7-Dichloropyrazolo[1,5-a]pyrimidine
- CAS No.: 57489-77-7
- Formula:C6H3Cl2N3
- Molecular Weight:188.01
IUPAC Name: 5,7-dichloropyrazolo[1,5-a]pyrimidine
InChIKey: JMTFWCYVZOFHLR-UHFFFAOYSA-N
SMILES: ClC1=CC(Cl)=NC2=CC=NN21
Biological Activity: 5,7-Dichloropyrazolo[1,5-a]pyrimidine is a PDE10A inhibitor with a Ki of 24 μM. 5,7-Dichloropyrazolo[1,5-a]pyrimidine serves as a key intermediate in the synthesis of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives (HIV-1 non-nucleoside reverse transcriptase inhibitors). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used for the research of schizophrenia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5,7-Dichloropyrazolo[1,5-a]pyrimidine | 99.69% | 5,7-Dichloropyrazolo[1,5-a]pyrimidine is a PDE10A inhibitor with a Ki of 24 μM. 5,7-Dichloropyrazolo[1,5-a]pyrimidine serves as a key intermediate in the synthesis of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives (HIV-1 non-nucleoside reverse transcriptase inhibitors). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used for the research of schizophrenia. | ||||||||||||||||||||
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References
- [1]. Raheem IT, et al. Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorg Med Chem Lett. 2016;26(1):126-132. [Content Brief]
- [2]. Tian Y, et al. Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives. Bioorg Med Chem. 2014 Apr 1;22(7):2052-9. [Content Brief]
