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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
fourth-stage larvae
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "fourth-stage larvae" in MCE Product Catalog:
Cat. No.: HY-184373
CAS No.: 1340790-22-8
Synonyms: SN639
SN00799639 (SN639) is an inhibitor of Haemonchus contortus. SN00799639 inhibits the motility of exsheathed third-stage larvae of Haemonchus contortus with an IC50 of 8.4 μM. SN00799639 inhibits the development of exsheathed third-stage larvae of Haemonchus contortus into fourth-stage larvae with an IC50 of 0.29 μM. SN00799639 shows no significant cytotoxicity against human mammary epithelial cells. SN00799639 can be used for research on Haemonchus contortus infection .
Cat. No.: HY-171722
CAS No.: 1355681-08-1
Synonyms: Asc-C9
Target:
Ascr#10 (Asc-C9) is an orally active thermogenesis inducer and insecticide that can be obtained from Monochamus alternatus. Ascr#10 binds to the insect adipokinetic hormone (AKH) receptor (Ka=272 µM) and stimulates mitochondrial biogenesis via the PGC1α-UCP4 axis. Consequently, Ascr#10 induces UCP4-mediated uncoupled respiration, reduces the ATP/ADP ratio and accelerates lipid mobilization, thereby driving the thermogenesis process. Ascr#10 delays pupation and exerts specific chemotaxis toward dispersive fourth-stage pinewood nematode LIV larvae. Ascr#10 promotes cold acclimation of Monochamus alternatus larvae through metabolic inhibition and cryoprotectant accumulation, enhancing their survival rate under cold stress. Ascr#10 also induces browning of white adipose tissue and activates brown adipose tissue in mice, thereby helping the body resist cold and tumor growth. Ascr#10 can be widely applied to research related to pine wilt disease, lung tumors and cold stress .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
