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Cat. No.: HY-184373

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SN00799639

(Synonyms: SN639)

SN00799639 (SN639) is an inhibitor of Haemonchus contortus. SN00799639 inhibits the motility of exsheathed third-stage larvae of Haemonchus contortus with an IC₅₀ of 8.4 μM. SN00799639 inhibits the development of exsheathed third-stage larvae of Haemonchus contortus into fourth-stage larvae with an IC₅₀ of 0.29 μM. SN00799639 shows no significant cytotoxicity against human mammary epithelial cells. SN00799639 can be used for research on Haemonchus contortus infection.

For research use only. We do not sell to patients.

CAS No.: 1340790-22-8
Formula: C₁₇H₁₈N₄OS
Molecular Weight:326.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

SN00799639 Chemical Structure

CAS No.: 1340790-22-8

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Description

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In Vitro

SN00799639 (SN639) inhibits Haemonchus contortus xL3 motility with an IC₅₀ of 8.4 μM and L4 development with an IC₅₀ of 0.29 μM, while exhibiting no significant cytotoxicity against human MCF10A cells (IC₅₀ > 50 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1340790-22-8
Molecular Weight 326.42
Formula C₁₇H₁₈N₄OS
SMILES

O=C(C1=CC=NN1C)NCC2=CC=C(C3=NC(CC)=CS3)C=C2
Synonyms

SN639
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Le TG, et al. Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity. Journal of medicinal chemistry. 2019 Apr 11;62(7):3367-3380. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SN00799639

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SN00799639 Related Classifications

HY-184373 Related Classifications