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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
hCPT
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "hCPT" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-N0095
CAS No.: 19685-09-7
Synonyms: 10-hCPT; 10-Hydroxycamptothecin
Category:
Pyrrole Alkaloids Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Alkaloids Monophenols Phenols Disease Research Fields Cancer
Target:
Cat. No.: HY-N0275
CAS No.: 64439-81-2
Synonyms: (±)-10-hCPT
Category:
Pyrrole Alkaloids Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Alkaloids Monophenols Phenols Disease Research Fields Cancer
Target:
Cat. No.: HY-13622
CAS No.: 220997-99-9
Synonyms: BN 80927
Target:
Research Areas:
Elomotecan hydrochloride (BN 80927) is an orally active, potent inhibitor of topoisomerases I and II and a homocamptothecin (hCPT) analogue. Elomotecan hydrochloride possesses a dual inhibitory mechanism: it acts as a topoisomerase I poison by stabilizing the DNA-enzyme complex while simultaneously serving as a catalytic inhibitor of topoisomerase II. Elomotecan hydrochloride is used in research concerning various advanced and multidrug-resistant (MDR) solid tumors (such as prostate, colon, and breast cancers) .
Cat. No.: HY-13622A
CAS No.: 220998-10-7
Synonyms: BN 80927 free base
Target:
Research Areas:
Elomotecan (BN 80927 free base) is an orally active, potent inhibitor of topoisomerases I and II and a homocamptothecin (hCPT) analogue. Elomotecan possesses a dual inhibitory mechanism: it acts as a topoisomerase I poison by stabilizing the DNA-enzyme complex while simultaneously serving as a catalytic inhibitor of topoisomerase II. Elomotecan is used in research concerning various advanced and multidrug-resistant (MDR) solid tumors (such as prostate, colon, and breast cancers) .
Cat. No.: HY-170842
TDK-HCPT is a small-molecule conjugate that links glutathione-sensitive thiamine disulfide to the chemotherapy drug 10-Hydroxycamptothecin (HY-N0095) via a thioketal bond. TDK-HCPT can target tumor cells and prolong the retention of chemotherapy agents within tumor cells. TDK-HCPT can inhibit tumor growth, induce apoptosis of tumor cells, and has anti-tumor activity .
Cat. No.: HY-N0095S
CAS No.: 1330277-66-1
Synonyms: 10-hCPT-d5; 10-Hydroxycamptothecin-d5
Cat. No.: HY-N0095R
CAS No.: 19685-09-7
Synonyms: 10-hCPT (Standard); 10-Hydroxycamptothecin (Standard)
Cat. No.: HY-N0275R
CAS No.: 64439-81-2
Synonyms: (±)-10-hCPT (Standard)
Category:
Alkaloids Monophenols Pyrrole Alkaloids Phenols Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae
Target:
Cat. No.: HY-181694
SeSA-HCPT is an orally active dual-target inhibitor integrating Topo I and HDAC inhibition. SeSA-HCPT induces potent DNA damage, apoptosis, S-phase arrest in prostate cancer cells. SeSA-HCPT inhibits cancer cells proliferation and migration. SeSA-HCPT impairs homologous recombination by suppressing KIF4A-RAD51 signaling. SeSA-HCPT markedly inhibits CRPC tumor growth with minimal systemic toxicity .
Cat. No.: HY-13622B
Synonyms: BN 80927 TFA
Target:
Research Areas:
Elomotecan TFA (BN 80927 TFA) is an orally active, potent inhibitor of topoisomerases I and II and a homocamptothecin (hCPT) analogue. Elomotecan TFA possesses a dual inhibitory mechanism: it acts as a topoisomerase I poison by stabilizing the DNA-enzyme complex while simultaneously serving as a catalytic inhibitor of topoisomerase II. Elomotecan TFA is used in research concerning various advanced and multidrug-resistant (MDR) solid tumors (such as prostate, colon, and breast cancers) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
