3 Results for "

human BAG3

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "human BAG3" in MCE Product Catalog:

Cat. No.: HY-156278
CAS No.: 3074495-82-9
Purity:  99.76%
Target:  

Apoptosis Autophagy

Research Areas:  

Cancer

FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the Ki of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells .
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Cat. No.: HY-RS01344
Research Areas:  

Others

BAG3 Human Pre-designed siRNA Set A contains three designed siRNAs for BAG3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P992379
Synonyms: BAG3-H2L4

Target:  

Bcl-2 Family

Research Areas:  

Cancer

IB001 is a humanized anti-BAG3 antibody that inhibits BAG3, with a KD value of 14.4 nM for human BAG3. IB001 blocks BAG3-dependent monocyte/macrophage activation, interferes with the interaction between BAG3 and IFITM-2, and disrupts tumor microenvironment signaling pathways. IB001 inhibits tumor growth, reduces α-SMA-positive fibroblasts, and blocks BAG3-dependent IL-6 release. IB001 accumulates in a time-dependent manner in pancreatic ductal adenocarcinoma tumors. IB001 can be used for research related to pancreatic ductal adenocarcinoma .
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