Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
human CAXII
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "human CAXII" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P72866
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CA12; CDNA FLJ20151 Fis, Clone COL08412; Carbonic Anhydrase 12; Carbonic Dehydratase; Carbonic Anhydrase XII; Carbonic Anhydrase; HsT18816; CA12 Protein; Tumor Antigen HOM-RCC-3.1.3; T18816; Carbonate Dehydratase XII; CAXII; CA-XII
Cat. No.: HY-169195
Target:
Research Areas:
CAIX/CAXII-IN-3 (compound 11) is an inhibitor of CAIX/CAXII, with an IC50 value of less than 65 nM. CAIX/CAXII-IN-3 inhibits the proliferation of human melanoma cells .
Cat. No.: HY-178030
Research Areas:
CAXII-IN-3 is an effective carbonic anhydrase (CA XII) inhibitor with a Ki of 53 nM. CAXII-IN-3 exhibits selective inhibition against multiple human CA subtypes with Kis of 5.3 μM, 75 nM, 1.9 μM, > 10 μM against CA I, CA II, CA IV and CA IX. CAXII-IN-3 mainly inhibits CA II and XII, and reduces aqueous humor production. CAXII-IN-3 exhibits β3-AR agonistic activity, can dilate retinal blood vessels, and improve optic nerve perfusion. CAXII-IN-3 can be used in the research of ocular disorders such as glaucoma .
Cat. No.: HY-187173
Target:
Research Areas:
CAXII-IN-4 is a human carbonic anhydrase XII (hCA XII) inhibitor with Ki values of 4.9, 3079, 62.5 and 58.4 nM against hCA XII, hCA I, hCA II and hCA IX, respectively, showing high selectivity toward tumor-associated hCA XII. CAXII-IN-4 binds to the active site of hCA XII via a classic sulfamide binding mode, coordinates with Zn 2+, forms a hydrogen bond with Ser133, and stabilizes the enzyme complex to reduce structural deviation. CAXII-IN-4 possesses both lipophilicity and polarity, and is predicted to have superior membrane permeability and oral absorbability. CAXII-IN-4 can be used in studies related to tumor-associated carbonic anhydrase inhibition .
Cat. No.: HY-P86796
Synonyms: CA 12 antibody; CA XII antibody; CA-XII antibody; CA12 antibody; CAH12_human antibody; Carbonate dehydratase XII antibody; Carbonic anhydrase 12 antibody; Carbonic anhydrase XII antibody; Carbonic dehydratase antibody; CAXII antibody; CA 12 antibody; CA XII antibody; CA-XII antibody; CA12 antibody; CAH12_human antibody; Carbonate dehydratase XII antibody; Carbonic anhydrase 12 antibody; Carbonic anhydrase XII antibody; Carbonic dehydratase antibody; CAXII antibody; FLJ20151 antibody; HsT18816 antibody; T18816 antibody; Tumor antigen HOM RCC 3.1.3 antibody; Tumor antigen HOM-RCC-3.1.3 antibody;
Cat. No.: HY-183374
Research Areas:
NYM074 is a carbonic anhydrase IX (CAIX) ligand. NYM074 binds specifically to human CAIX to enable targeted radionuclide delivery. NYM074 supports dual radiolabeling with 68Ga for positron emission tomography (PET) imaging and 177Lu for radionuclide applications. NYM074 can be used for the research of clear cell renal cell carcinoma .
Cat. No.: HY-P71720
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CA12; CDNA FLJ20151 Fis, Clone COL08412; Carbonic Anhydrase 12; Carbonic Dehydratase; Carbonic Anhydrase XII; Carbonic Anhydrase; HsT18816; CA12 Protein; Tumor Antigen HOM-RCC-3.1.3; T18816; Carbonate Dehydratase XII; CAXII; CA-XII
Species:
Source:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
