11 Results for "

human CTR

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "human CTR" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-10302
CAS No.: 957116-20-0
Purity:  98.02%
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.
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1
1 Cited Publications
Cat. No.: HY-P72011
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC31A1; Copper Transporter 1; Prev. COPT1; Copper Transport 1 Homolog (S. Cerevisiae); CTR1; Copper Transport 1 Homolog; HCTR1; Copper Transport Protein; Solute Carrier Family 31 (Copper Transporter), Member 1; NSCT; High Affinity Copper Uptake Protein 1
Species:  
Source:  
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Cat. No.: HY-P10798
CAS No.: 2883634-40-8
Synonyms: LY-3841136
Research Areas:  

Metabolic Disease

Eloralintide (LY-3841136) is an amylin receptor agonist with human AMY1R EC50 23.9 pM and human AMY3R EC50 253.8 pM. Eloralintide induces decreased appetite, reduced food intake, body weight and fat mass loss, prolonged plasma calcium 2+ reduction, and weak conditioned taste avoidance. Eloralintide can be used for the research of obesity .
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Cat. No.: HY-P10798A
Synonyms: LY-3841136 sodium
Research Areas:  

Metabolic Disease

Eloralintide sodium is an Amylin Receptor agonist. Eloralintide sodium selectively activates AMY1R and AMY3R in cells expressing human or rat AMY1R, AMY3R or CTR. Eloralintide sodium activates AMYRs and CTR in rats, inducing a sustained decrease in plasma Ca 2+ levels. Eloralintide sodium reduces appetite and body weight in both lean and obese rats. Eloralintide sodium can be used for research related to obesity .
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Cat. No.: HY-160267
CAS No.: 950403-60-8
Target:  

HIV DNA/RNA Synthesis

Research Areas:  

Infection Neurological Disease Cancer

iPAF1C is a inhibitor of the polymerase-associated factor 1 complex (PAF1C) with specific targeting to the PAF1 binding groove of CTR9 (a key subunit of PAF1C). iPAF1C disrupts PAF1C assembly by interfering with the PAF1-CTR9 interaction. iPAF1C selectively impairs BRD4-mediated recruitment of PAF1 to chromatin at hypoxia-responsive genes and inhibits RNA polymerase II (RNAPII) pause release. iPAF1C increases the population of HIV-1 NL4.3 Nef-IRES-GFP infected primary human CD4 +T cells in a dose-dependent manner. PAF1C can be used for the study of infection and diseases associated with abnormal hypoxic adaptation (e.g., cancers, neurological disorders) .
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Cat. No.: HY-P4863
CAS No.: 1678415-18-3
Target:  

CGRP Receptor

Biotinyl-Amylin (human) is a biotin-labeled derivative of Amylin, amide, human (HY-P1070). Biotinyl-Amylin (human) acts as a competitive agonist for the Calcitonin Receptor (CTR) and for the Amylin receptors (AMY1, AMY2, and AMY3) formed by the association of CTR with RAMP1/2/3. By mimicking endogenous human amylin, Biotinyl-Amylin (human) binds to and activates CTR and AMY receptors, thereby initiating downstream signaling pathways involving cAMP, CREB, and ERK1/2, while retaining high-affinity receptor binding and activation capabilities. Biotinyl-Amylin (human) is primarily utilized in studies investigating the metabolic regulatory mechanisms underlying obesity and diabetes; it is also applicable to pharmacological research, receptor localization studies, and ligand-binding assays related to Amylin receptors in the context of Alzheimer's disease .
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Cat. No.: HY-RS03316
Research Areas:  

Others

CTR9 Human Pre-designed siRNA Set A contains three designed siRNAs for CTR9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-185107
CAS No.: 3108095-52-6
Research Areas:  

Metabolic Disease

CTR/AMYR modulator-2 is a dual agonist of human amylin receptor 3 (AMY3R) and calcitonin receptor (CTR). CTR/AMYR modulator-2 activates AMY3R and CTR, stimulating Rel EC50 of cAMP production in UMUC3 cells by 4 nM and 1 nM, respectively. CTR/AMYR modulator-2 may be used in research on type 2 diabetes and obesity .
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Cat. No.: HY-P74359
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CALCR; CTR; Calcitonin Receptor; CTR1; CT-R; CRT
Species:  
Source:  
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Cat. No.: HY-10302R
CAS No.: 957116-20-0
Research Areas:  

Neurological Disease

MK-3207 hydrochloride (Standard) is the analytical standard of MK-3207 hydrochloride (HY-10302). This product is intended for research and analytical applications. MK-3207 hydrochloride is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.
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Cat. No.: HY-P11830
Target:  

Amylin Receptor

Research Areas:  

Metabolic Disease

UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity .
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