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human CTR

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By Targets:	Amylin Receptor (3) Calcium Channel (2) CGRP Receptor (3) DNA/RNA Synthesis (1) HIV (1) Reference Standards (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Infection (1) Metabolic Disease (4) Neurological Disease (4)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Peptides

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10798

Eloralintide LY-3841136	Amylin Receptor Calcium Channel	Metabolic Disease
Eloralintide (LY-3841136) is an amylin receptor agonist with human AMY1R EC₅₀ 23.9 pM and human AMY3R EC₅₀ 253.8 pM. Eloralintide induces decreased appetite, reduced food intake, body weight and fat mass loss, prolonged plasma calcium ²⁺ reduction, and weak conditioned taste avoidance. Eloralintide can be used for the research of obesity .

HY-P10798A

Eloralintide sodium LY-3841136 sodium	Amylin Receptor Calcium Channel	Metabolic Disease
Eloralintide sodium is an Amylin Receptor agonist. Eloralintide sodium selectively activates AMY1R and AMY3R in cells expressing human or rat AMY1R, AMY3R or *CTR. Eloralintide sodium activates AMYRs and CTR* in rats, inducing a sustained decrease in plasma Ca ²⁺ levels. Eloralintide sodium reduces appetite and body weight in both lean and obese rats. Eloralintide sodium can be used for research related to obesity .

HY-10302

MK-3207 Hydrochloride 5 Publications Verification	CGRP Receptor	Neurological Disease
MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC₅₀ of 0.12 nM and K_i of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.

HY-160267

iPAF1C	HIV DNA/RNA Synthesis	Infection Neurological Disease Cancer
iPAF1C is a inhibitor of the polymerase-associated factor 1 complex (PAF1C) with specific targeting to the PAF1 binding groove of CTR9 (a key subunit of PAF1C). iPAF1C disrupts PAF1C assembly by interfering with the PAF1-CTR9 interaction. iPAF1C selectively impairs BRD4-mediated recruitment of PAF1 to chromatin at hypoxia-responsive genes and inhibits RNA polymerase II (RNAPII) pause release. iPAF1C increases the population of HIV-1 NL4.3 Nef-IRES-GFP infected primary human CD4 ⁺T cells in a dose-dependent manner. PAF1C can be used for the study of infection and diseases associated with abnormal hypoxic adaptation (e.g., cancers, neurological disorders) .

HY-P4863

*Biotinyl-Amylin (human)*	CGRP Receptor	Neurological Disease Metabolic Disease
Biotinyl-Amylin (human) is a biotin-labeled derivative of Amylin, amide, human (HY-P1070). Biotinyl-Amylin (human) acts as a competitive agonist for the Calcitonin Receptor (CTR) and for the Amylin receptors (AMY₁, AMY₂, and AMY₃) formed by the association of CTR with RAMP1/2/3. By mimicking endogenous human amylin, Biotinyl-Amylin (human) binds to and activates CTR and AMY receptors, thereby initiating downstream signaling pathways involving cAMP, CREB, and ERK1/2, while retaining high-affinity receptor binding and activation capabilities. Biotinyl-Amylin (human) is primarily utilized in studies investigating the metabolic regulatory mechanisms underlying obesity and diabetes; it is also applicable to pharmacological research, receptor localization studies, and ligand-binding assays related to Amylin receptors in the context of Alzheimer's disease .

HY-RS03316

CTR9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CTR9 Human Pre-designed siRNA Set A contains three designed siRNAs for CTR9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CTR9 Human Pre-designed siRNA Set A CTR9 Human Pre-designed siRNA Set A

HY-10302R

MK-3207 hydrochloride (Standard)	Reference Standards CGRP Receptor	Neurological Disease
MK-3207 hydrochloride (Standard) is the analytical standard of MK-3207 hydrochloride (HY-10302). This product is intended for research and analytical applications. MK-3207 hydrochloride is a potent and orally bioavailable CGRP receptor antagonist with IC₅₀ of 0.12 nM and K_i of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.

HY-P11830

UDA-6	Amylin Receptor	Metabolic Disease
UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity .

Cat. No.	Product Name	Target	Research Area

HY-P10798

Eloralintide LY-3841136	Amylin Receptor Calcium Channel	Metabolic Disease
Eloralintide (LY-3841136) is an amylin receptor agonist with human AMY1R EC₅₀ 23.9 pM and human AMY3R EC₅₀ 253.8 pM. Eloralintide induces decreased appetite, reduced food intake, body weight and fat mass loss, prolonged plasma calcium ²⁺ reduction, and weak conditioned taste avoidance. Eloralintide can be used for the research of obesity .

HY-P10798A

Eloralintide sodium LY-3841136 sodium	Amylin Receptor Calcium Channel	Metabolic Disease
Eloralintide sodium is an Amylin Receptor agonist. Eloralintide sodium selectively activates AMY1R and AMY3R in cells expressing human or rat AMY1R, AMY3R or *CTR. Eloralintide sodium activates AMYRs and CTR* in rats, inducing a sustained decrease in plasma Ca ²⁺ levels. Eloralintide sodium reduces appetite and body weight in both lean and obese rats. Eloralintide sodium can be used for research related to obesity .

HY-P4863

*Biotinyl-Amylin (human)*	CGRP Receptor	Neurological Disease Metabolic Disease
Biotinyl-Amylin (human) is a biotin-labeled derivative of Amylin, amide, human (HY-P1070). Biotinyl-Amylin (human) acts as a competitive agonist for the Calcitonin Receptor (CTR) and for the Amylin receptors (AMY₁, AMY₂, and AMY₃) formed by the association of CTR with RAMP1/2/3. By mimicking endogenous human amylin, Biotinyl-Amylin (human) binds to and activates CTR and AMY receptors, thereby initiating downstream signaling pathways involving cAMP, CREB, and ERK1/2, while retaining high-affinity receptor binding and activation capabilities. Biotinyl-Amylin (human) is primarily utilized in studies investigating the metabolic regulatory mechanisms underlying obesity and diabetes; it is also applicable to pharmacological research, receptor localization studies, and ligand-binding assays related to Amylin receptors in the context of Alzheimer's disease .

HY-P11830

UDA-6	Amylin Receptor	Metabolic Disease
UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity .

Species:	Human (2)
Tag:	SUMO (1) His (1) Fc (1)
Source:	HEK293 (1) E. coli Cell-free (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74359

	*Calcitonin R Protein, Human* (HEK293, hFc)** Calcitonin R; Calcitonin receptor; CALCR; CRT; CTR; CTR1	Human	HEK293
	Calcitonin R protein, a receptor for calcitonin, utilizes G proteins to activate adenylyl cyclase. Despite being sensitive to cholera toxin, it exhibits limited coupling to G proteins, leading to the inability to effectively activate adenylyl cyclase. Notably, following ligand binding, Calcitonin R does not undergo the conventional process of receptor internalization. Calcitonin R Protein, Human (130a.a, HEK293, Fc) is the recombinant human-derived Calcitonin R, expressed by HEK293, with N-hFc labeled tag. The total length of Calcitonin R Protein, Human (130a.a, HEK293, Fc) is 130 a.a..

HY-P72011

	*SLC31A1 Protein, Human* (Cell-Free, His-SUMO)** 1 Publications Verification Copper transport 1 homolog; Copper transporter 1; COPT1; COPT1_human; CTR1; hCTR1; High affinity copper uptake protein 1; SLC31A1; solute carrier family 31 copper tansporters; member 1; Solute carrier family 31 member 1	Human	E. coli Cell-free
	The SLC31A1 protein is an important uniporter that can transport copper(1+) from the extracellular space into the cytoplasm with remarkable specificity and deliver it directly to molecular chaperones such as ATOX1. This process tightly regulates intracellular copper(1+) levels and may be involved in intestinal copper absorption. SLC31A1 Protein, Human (Cell-Free, His-SUMO) is the recombinant human-derived SLC31A1 protein, expressed by E. coli Cell-free , with N-SUMO, N-6*His labeled tag.

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CTR9 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CTR9 Human Pre-designed siRNA Set A contains three designed siRNAs for CTR9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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