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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
human P2Y12
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "human P2Y12" in MCE Product Catalog:
1
Research Areas:
N6-(4-Hydroxybenzyl) adenosine (Para-topolin riboside) is an equilibrative nucleoside transporter 1 (ENT1) inhibitor and a selective agonist of adenosine A2a receptor (A2aR), and also exhibits activity against P2Y12 receptor. N6-(4-Hydroxybenzyl) adenosine reduces ethanol intake and preference, attenuates operant conditioning-induced ethanol place preference, decreases the value of ethanol-related rewards, and inhibits collagen-induced platelet aggregation. N6-(4-Hydroxybenzyl) adenosine can be used in studies related to alcohol use disorder .
1
1 Cited Publications
Cat. No.: HY-P87002
Synonyms: ADP glucose receptor antibody; ADP-glucose receptor antibody; ADPG R antibody; ADPG-R antibody; ADPGR antibody; BDPLT8 antibody; G protein coupled receptor SP1999 antibody; Gi coupled ADP receptor HORK 3 antibody; Gi coupled ADP receptor HORK3 antibody; HORK 3 antibody; ADP glucose receptor antibody; ADP-glucose receptor antibody; ADPG R antibody; ADPG-R antibody; ADPGR antibody; BDPLT8 antibody; G protein coupled receptor SP1999 antibody; Gi coupled ADP receptor HORK 3 antibody; Gi coupled ADP receptor HORK3 antibody; HORK 3 antibody; HORK3 antibody; P2RY 12 antibody; P2RY12 antibody; P2T(AC) antibody; P2Y 12 antibody; P2Y purinoceptor 12 antibody; P2Y(12)R antibody; P2Y(AC) antibody; P2Y(ADP) antibody; P2Y(cyc) antibody; P2Y12 antibody; P2Y12 platelet ADP receptor antibody; P2Y12_human antibody; Platelet ADP receptor antibody; Purinergic receptor P2RY12 antibody; Purinergic receptor P2Y G protein coupled 12 antibody; Purinergic receptor P2Y12 antibody; Putative G protein coupled receptor antibody; SP 1999 antibody; SP1999 antibody;
Synonyms: 2-Methylthioadenosine diphosphate trisodium; 2-Methylthio-ADP trisodium
Target:
Research Areas:
2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .
Cat. No.: HY-108648A
CAS No.: 34983-48-7
Synonyms: 2-Methylthioadenosine diphosphate; 2-Methylthio-ADP
Target:
Research Areas:
2-MeSADP is a P2Y receptor agonist, with an EC50 of 5 nM for human P2Y12, EC50 values of 19 nM and 13 nM for human P2Y13, and an EC50 of 6.2 nM for mouse P2Y13. It shows slightly higher selectivity for P2Y12 over human P2Y13. 2-MeSADP triggers increases in intracellular calcium levels, Gi-mediated cAMP inhibition, adenylate cyclase inhibition and downstream signal transduction. 2-MeSADP can be used in research related to glaucoma .
Cat. No.: HY-173447
CAS No.: 344402-39-7
8-BuS-AMP is a NTPDase1 inhibitor and a CD73/CD39 inhibitor, with an IC50 of 35 μM and a Ki value of 0.292 μM against human NTPDase1; its Ki values against human CD73 and CD39 are 1.19 μM and 0.847 μM, respectively. 8-BuS-AMP binds to the substrate-binding pockets of NTPDase1 and CD73 to effectively block the conversion of ATP and AMP to adenosine, thereby enhancing the activation and proliferation of human peripheral T lymphocytes. 8-BuS-AMP possesses excellent enzymatic hydrolysis resistance and metabolic stability, resists hydrolysis by multiple NTPDase subtypes, and shows no activity against P2Y1 and P2Y12 receptors. 8-BuS-AMP can be used in purinergic signaling pathway and cancer-related studies .
Cat. No.: HY-137749A
Synonyms: 2'-Deoxy-3'-MANT-ADP trisodium
Target:
Research Areas:
MANT-dADP (trisodium) (2'-Deoxy-3'-MANT-ADP (trisodium)) is a fluorescent nucleotide derivative, with an emission maximum of 453 nm upon excitation at 350 nm. MANT-dADP (trisodium) can decrease inositol phoshate formation in CHO-K1 cells that express human purinergic P2Y12 receptor. MANT-dADP (trisodium) can be studied in research on the interaction between cardiac troponin I and myofibrils .
Cat. No.: HY-W419570
CAS No.: 478005-11-7
Target:
Research Areas:
(Rac)-BX 048 is a BX 048 racemate. BX 048 is a P2Y12 receptor antagonist. BX 048 inhibits ADP-induced platelet aggregation in human, dog and rat whole blood. BX 048 also inhibits Arachidonic acid (HY-109590) induced platelet aggregation (IC50 of 15 μM) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
