475193-31-8
Chemical Structure
2-MeS-ADP trisodium
Synonym(s): 2-Methylthioadenosine diphosphate trisodium; 2-Methylthio-ADP trisodium
- CAS No.: 475193-31-8
- Formula:C11H14N5Na3O10P2S
- Molecular Weight:539.24
IUPAC Name: sodium ((2R,3S,4R,5R)-5-(6-amino-2-(methylthio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl diphosphate
InChIKey: DYNGCIHMNWOBSU-MSQVLRTGSA-K
SMILES: O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O
Biological Activity:
2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3].
The product specifications provided below refer solely to the active content of 2-MeS-ADP trisodium.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-MeS-ADP trisodium | 99.72% | 2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1. The product specifications provided below refer solely to the active content of 2-MeS-ADP trisodium. |
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Similarity Score 0.90
HY-1013702-Methylthio-ATP tetrasodium -
Similarity Score 0.86
HY-1030642-Methylthio-AMP sodium -
Similarity Score 0.85
HY-131776A2-Chloro-ADP sodium solution (10 mM) -
Similarity Score 0.80
HY-108648A2-MeSADP -
Similarity Score 0.78
HY-137325A2-Chloro-ATP sodium -
Similarity Score 0.77
HY-1374182-MeS-ATP -
Similarity Score 0.76
HY-1259892-Methylthio-AMP -
Similarity Score 0.75
HY-D0199Adenosine 5'-diphosphate disodium -
Similarity Score 0.73
HY-134361ATP-γ-S tetrasodium -
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References
- [1]. Zhang FL, et al. P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse. J Pharmacol Exp Ther. 2002;301(2):705-713. [Content Brief]
- [2]. Sak K, et al. A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch Biochem Biophys. 2002;397(1):131-136. [Content Brief]
- [3]. Macfarlane DE, et al. 2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J Clin Invest. 1983;71(3):420-428. [Content Brief]
