ATP-γ-S tetrasodium
Based on 1 publication(s) in Google Scholar
ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis.
For research use only. We do not sell to patients.
- CAS No.: 88453-52-5
- Formula: C10H12N5Na4O12P3S
- Molecular Weight:611.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) ATP-γ-S tetrasodium
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Biological Activity
ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase[1].
ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 88453-52-5
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Molecular Weight 611.17
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Formula C10H12N5Na4O12P3S
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SMILES
O[C@@H]([C@H]([C@@](N1C=NC2=C1N=CN=C2N)([H])O3)O)[C@H]3COP(OP(OP(O[Na])(S[Na])=O)(O[Na])=O)(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Adv Res
Mechanosensitive ion channel Piezo1 mediates mechanical ventilation-exacerbated ARDS-associated pulmonary fibrosis. [Abstract]2023 Nov:53:175-186. PMID: 36526145
ATP-γ-S tetrasodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186. [Abstract]
ATPγS tetralithium salt (γ-ATP; 100 μM; 48 h). The expression of E-cadherin, cytokeratin-8, vimentin and α-SMA in BEAS-2B cells was measured by Western blot analysis.
ATP-γ-S tetrasodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186. [Abstract]
ATPγS tetralithium salt (γ-ATP; 100 μM; 48 h). The expression levels of E-cadherin, cytokeratin-8, vimentin and SMA were confirmed by cell immunostaining.
ATP-γ-S tetrasodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186. [Abstract]
ATPγS tetralithium salt (γ-ATP; 100 μM/mouse; intratracheal instillation). The lung injury score and lung fibrosis score were determined based on lung histological analysis with HE staining and Masson’s trichrome staining.
ATP-γ-S tetrasodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186. [Abstract]
ATPγS tetralithium salt (γ-ATP; 100 μM/mouse; intratracheal instillation). Lung tissue level of hydroxyproline on day 14.
ATP-γ-S tetrasodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186. [Abstract]
ATPγS tetralithium salt (γ-ATP; 100 μM/mouse; intratracheal instillation). The protein expression of E-cadherin, cytokeratin-8, vimentin and α-SMA was measured by Western blot analysis.
Purity & Documentation
References
[1]. Matthew L Peck, et al. Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9(10):1180-7. [Content Brief]
[2]. Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202(1):47-55. [Content Brief]
[3]. Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L319-24. [Content Brief]
[4]. Ortal Danino, et al. ATP-γ-S-(α,β-CH2) protects against oxidative stress and amyloid beta toxicity in neuronal culture. Biochem Biophys Res Commun. 2015 May 1;460(2):446-50. [Content Brief]
[5]. J W Lee, et al. Inhibition of recA protein promoted ATP hydrolysis. 1. ATP gamma S and ADP are antagonistic inhibitors. Biochemistry. 1990 Aug 21;29(33):7666-76. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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