ATP-γ-S tetrasodium

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ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis.

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CAS No. : 88453-52-5

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Other In-stock Forms of ATP-γ-S tetrasodium:

ATPγS tetralithium salt

Other Forms of ATP-γ-S tetrasodium:

ATPγS tetralithium salt In-stock

1 Publications Citing Use of MCE ATP-γ-S tetrasodium

•J Adv Res. 2023 Nov:53:175-186. [Abstract]

IHC

In Vivo Efficacy Study

: ATP-γ-S tetrasodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186. [Abstract]; ATPγS tetralithium salt (γ-ATP; 100 μM; 48 h). The expression of E-cadherin, cytokeratin-8, vimentin and α-SMA in BEAS-2B cells was measured by Western blot analysis.

: ATP-γ-S tetrasodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186. [Abstract]; ATPγS tetralithium salt (γ-ATP; 100 μM; 48 h). The expression levels of E-cadherin, cytokeratin-8, vimentin and SMA were confirmed by cell immunostaining.

: ATP-γ-S tetrasodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186. [Abstract]; ATPγS tetralithium salt (γ-ATP; 100 μM/mouse; intratracheal instillation). The lung injury score and lung fibrosis score were determined based on lung histological analysis with HE staining and Masson’s trichrome staining.

: ATP-γ-S tetrasodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186. [Abstract]; ATPγS tetralithium salt (γ-ATP; 100 μM/mouse; intratracheal instillation). Lung tissue level of hydroxyproline on day 14.

: ATP-γ-S tetrasodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Nov:53:175-186. [Abstract]; ATPγS tetralithium salt (γ-ATP; 100 μM/mouse; intratracheal instillation). The protein expression of E-cadherin, cytokeratin-8, vimentin and α-SMA was measured by Western blot analysis.

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Description	ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis^[1]^[2]^[3]^[4]^[5].
In Vitro	ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase^[1]. ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. ATP-γ-S tetrasodium Related Antibodies
In Vivo	ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture^[3]. ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	611.17
Formula	C₁₀H₁₂N₅Na₄O₁₂P₃S
CAS No.	88453-52-5
SMILES	O[C@@H]([C@H]([C@@](N1C=NC2=C1N=CN=C2N)([H])O3)O)[C@H]3COP(OP(OP(O[Na])(S[Na])=O)(O[Na])=O)(O[Na])=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Matthew L Peck, et al. Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9(10):1180-7. [Content Brief] [2]. Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202(1):47-55. [Content Brief] [3]. Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L319-24. [Content Brief] [4]. Ortal Danino, et al. ATP-γ-S-(α,β-CH2) protects against oxidative stress and amyloid beta toxicity in neuronal culture. Biochem Biophys Res Commun. 2015 May 1;460(2):446-50. [Content Brief] [5]. J W Lee, et al. Inhibition of recA protein promoted ATP hydrolysis. 1. ATP gamma S and ADP are antagonistic inhibitors. Biochemistry. 1990 Aug 21;29(33):7666-76. [Content Brief]