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Results for "

human PDE3

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Recombinant Proteins

2

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-106739
    Motapizone

    NAT 05-239

    		 Phosphodiesterase (PDE) Inflammation/Immunology
    Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP .
    Motapizone
  • HY-111219
    Parogrelil hydrochloride

    NM-702; NT-702

    		 Phosphodiesterase (PDE) Others
    Parogrelil (hydrochloride) (NM-702) is a phosphodiesterase inhibitor with activity in inhibiting intermittent claudication. Parogrelil (hydrochloride) selectively inhibits PDE3, inhibits human platelet aggregation in vitro and rat aortic contraction, and improves walking distance and plantar surface temperature in the rat femoral artery ligation model, with better effects than cilostazol.
    Parogrelil hydrochloride
  • HY-RS10216
    PDE3A Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PDE3A Human Pre-designed siRNA Set A contains three designed siRNAs for PDE3A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PDE3A Human Pre-designed siRNA Set A
    PDE3A Human Pre-designed siRNA Set A
  • HY-RS10219
    PDE3B Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PDE3B Human Pre-designed siRNA Set A contains three designed siRNAs for PDE3B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PDE3B Human Pre-designed siRNA Set A
    PDE3B Human Pre-designed siRNA Set A
  • HY-113822
    Lixazinone hydrogensulfate

    RS-82856 hydrogensulfate

    		 Phosphodiesterase (PDE) Cardiovascular Disease Endocrinology
    Lixazinone (RS-82856) hydrogensulfate is a selective inhibitor of cGMP-inhibited phosphodiesterase (PDE3) with an IC50 value of 22 nM. Lixazinone hydrogensulfate exhibits positive inotropic effects, afterload reduction and antithrombotic properties. Lixazinone hydrogensulfate increases cyclic adenosine monophosphate (cAMP) levels in human platelets, inhibits thrombin-induced aggregation of human platelets, and blocks the photolabeling of PDE3 active sites by [ 32P]cGMP. Lixazinone hydrogensulfate can be used in the research of polycystic kidney disease and congestive heart failure .
    Lixazinone hydrogensulfate
  • HY-105931
    Lixazinone

    RS-82856

    		 Phosphodiesterase (PDE) Cardiovascular Disease Endocrinology
    Lixazinone (RS-82856) is a selective inhibitor of cGMP-inhibited phosphodiesterase (PDE3) with an IC50 value of 22 nM. Lixazinone exhibits positive inotropic effects, afterload reduction and antithrombotic properties. Lixazinone increases cyclic adenosine monophosphate (cAMP) levels in human platelets, inhibits thrombin-induced aggregation of human platelets, and blocks the photolabeling of PDE3 active sites by [ 32P]cGMP. Lixazinone can be used in the research of polycystic kidney disease and congestive heart failure .
    Lixazinone
  • HY-182271
    GPR61 Inverse agonist 3

    		Orphan GPCR GABA Receptor Phosphodiesterase (PDE) Metabolic Disease
    GPR61 Inverse agonist 3 is a selective and brain-penetrant GPR61 inverse agonist with human IC50 of 4.0 nM, mouse IC50 of 8.8 nM, human Ki of 0.34 nM, mouse Ki of 1.1 nM. GPR61 Inverse agonist 3 disrupts GPR61-Gαs protein interactions to abolish GPR61 constitutive activity. GPR61 Inverse agonist 3 moderately inhibits GABAA chloride channel and PDE3A1 with IC50 values of 4.6 and 8.9 μM. GPR61 Inverse agonist 3 shows no functional effect on food intake in adult mice co-administered with a pan-CYP inhibitor. GPR61 Inverse agonist 3 can be used for the research of cachexia/sarcopenia .
    GPR61 Inverse agonist 3

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