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Results for "

monomer-dimer equilibrium

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Fluorescent Dyes

Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-121817
    Sulfiram

    		Aldehyde Dehydrogenase (ALDH) Drug Intermediate Amyloid-β Infection Neurological Disease
    Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC50 value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease .
    Sulfiram
  • HY-184154
    LC1236

    		Thymidylate Synthase Cancer
    LC1236 is a thymidylate synthase (hTS) dimer dissociator with a target Kd of 7 μM and poor transmembrane permeability. LC1236 inhibits enzymatic activity by shifting the monomer-dimer equilibrium toward inactive monomers. LC1236 acts as a cytotoxic agent to inhibit cancer cell growth, and exerts synergistic cytotoxicity with electroporation via enhancing intracellular accumulation. LC1236 can be used in the research of cancers such as ovarian cancer and colorectal cancer .
    LC1236
  • HY-125749
    Coumarin-30

    		Fluorescent Dye Others
    Coumarin-30 is a coumarin-based fluorescent dye and environment-sensitive fluorescent probe (in aqueous medium, λex = 430 nm, λem = 495 nm). Coumarin-30 serves as a dopant for organic light-emitting diodes .
    Coumarin-30

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