95-05-6
Chemical Structure
Sulfiram
- CAS No.: 95-05-6
- Formula:C10H20N2S3
- Molecular Weight:264.47
InChIKey: CTPKSRZFJSJGML-UHFFFAOYSA-N
SMILES: S=C(N(CC)CC)SC(N(CC)CC)=S
Biological Activity: Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC50 value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease[1][2].
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Sulfiram | 96.35% | Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC50 value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease. | ||||||||||||||||||||
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Sulfiram (Standard) | ≥98% | Sulfiram (Standard) is the analytical standard of Sulfiram (HY-121817). This product is intended for research and analytical applications. Sulfiram, an ectoparasiticide, is a weak aldehyde dehydrogenase (ALDH) inhibitor. Sulfiram can be used for the study of scabies. | ||||||||||||||||||||
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References
- [1]. Mays DC, et al. Photolysis of sulfiram: a mechanism for its disulfiram-like reaction. Biochem Pharmacol. 1994;48(10):1917-1925. [Content Brief]
- [2]. Libeu CA, et al. Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One. 2012;7(6):e40027. [Content Brief]
