2. Apoptosis
  3. Thymidylate Synthase
  4. LC1236

LC1236 is a thymidylate synthase (hTS) dimer dissociator with a target Kd of 7 μM and poor transmembrane permeability. LC1236 inhibits enzymatic activity by shifting the monomer-dimer equilibrium toward inactive monomers. LC1236 acts as a cytotoxic agent to inhibit cancer cell growth, and exerts synergistic cytotoxicity with electroporation via enhancing intracellular accumulation. LC1236 can be used in the research of cancers such as ovarian cancer and colorectal cancer.

For research use only. We do not sell to patients.

LC1236

LC1236 Chemical Structure

CAS No. : 2756347-47-2

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LC1236 Related Antibodies

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Description

LC1236 is a thymidylate synthase (hTS) dimer dissociator with a target Kd of 7 μM and poor transmembrane permeability. LC1236 inhibits enzymatic activity by shifting the monomer-dimer equilibrium toward inactive monomers. LC1236 acts as a cytotoxic agent to inhibit cancer cell growth, and exerts synergistic cytotoxicity with electroporation via enhancing intracellular accumulation. LC1236 can be used in the research of cancers such as ovarian cancer and colorectal cancer[1][2].

In Vitro

LC1236 (50–100 μM; 72 h), when combined with electroporation, exhibited synergistically enhanced cytotoxicity in A2780 ovarian cancer cells, A2780/CP Cisplatin (HY-17394)-resistant ovarian cancer cells, and HCT116 colorectal adenocarcinoma cells, overcoming its intrinsic poor cell membrane permeability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LC1236 Related Antibodies
Molecular Weight

408.43

Formula

C21H16N2O5S
CAS No.
SMILES

O=C(NC1=CC=C(C(O)=O)C=C1)C(C2=CC=CC=C2)SC3=CC=C([N+]([O-])=O)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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LC1236 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC12362756347-47-2LC 1236LC-1236Thymidylate SynthaseA2780 ovarian carcinomapancreatic adenocarcinomaA2780/CP cisplatin-resistant ovarian carcinomaovarian cancerHCT116 colorectal adenocarcinomacolorectal cancercisplatin-resistant gynecological cancerhuman thymidylate synthaseInhibitorinhibitorinhibit

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