13 Results for "

random coil conformation

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "random coil conformation" in MCE Product Catalog:

3
Guanidine hydrochloride
Guanidine hydrochloride
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3 Cited Publications
Cat. No.: HY-B0178A
CAS No.: 50-01-1
Synonyms: Guanidinium chloride; Aminoformamidine hydrochloride
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Biochemical Assay Reagents

Guanidine hydrochloride (Guanidinium chloride) is a strong protein denaturant. Guanidine hydrochloride causes proteins to assume a random coil conformation .
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GALA
GALA
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Cat. No.: HY-P5423
CAS No.: 107658-43-5
Target:  

Exosomes Liposome

Research Areas:  

Cancer

GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems .
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6M Guanidine hydrochloride Solution
6M Guanidine hydrochloride Solution
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Cat. No.: HY-B0178B
CAS No.: 50-01-1
Synonyms: 6M Guanidinium chloride Solution; 6M Aminoformamidine hydrochloride Solution
6M Guanidine hydrochloride Solution (6M Guanidinium chloride Solution) is a strong protein denaturant. 6M Guanidine hydrochloride Solution causes proteins to assume a random coil conformation .
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Guanidine-13C,15N3 hydrochloride
Guanidine-13C,15N3 hydrochloride
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Cat. No.: HY-B0178AS
CAS No.: 285977-73-3
Synonyms: Guanidinium-13C,15N3 chloride; Aminoformamidine-13C,15N3 hydrochloride
Guanidine- 13C, 15N3 hydrochloride (Guanidinium- 13C, 15N3 (chloride)) is the 15N, 13C-labeled Guanidine hydrochloride (HY-B0178A). Guanidine hydrochloride is a strong protein denaturant. Guanidine hydrochloride causes proteins to assume a random coil conformation .
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Guanidine hydrochloride (Standard)
Guanidine hydrochloride (Standard)
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Cat. No.: HY-B0178AR
CAS No.: 50-01-1
Synonyms: Guanidinium chloride (Standard); Aminoformamidine hydrochloride (Standard)
Category:  

Natural Products Endogenous metabolite

Target:  

Reference Standards Biochemical Assay Reagents

Guanidine hydrochloride (Standard) (Guanidinium chloride (Standard)) is the analytical standard of Guanidine hydrochloride (HY-B0178A). This product is intended for research and analytical applications. Guanidine hydrochloride (Guanidinium chloride) is a strong protein denaturant. Guanidine hydrochloride causes proteins to assume a random coil conformation .
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Guanidine-d5 hydrochloride
Guanidine-d5 hydrochloride
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Cat. No.: HY-B0178AS1
CAS No.: 108694-93-5
Synonyms: Guanidinium-d5 chloride; Aminoformamidine-d5 hydrochloride
Guanidine-d5 hydrochloride (Guanidinium-d5 chloride) is the d5-labeled Guanidine hydrochloride (HY-B0178A). Guanidine hydrochloride is a strong protein denaturant. Guanidine hydrochloride causes proteins to assume a random coil conformation .
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HA2 peptide
HA2 peptide
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Cat. No.: HY-P11353
CAS No.: 117138-19-9
Target:  

Small Interfering RNA (siRNA) HIV

Research Areas:  

Infection Cancer

HA2 peptide is a potent pH-responsive fusion peptide derived from hemagglutinin (HA), corresponding to the N-terminal fusion peptide domain consisting of 23 amino acid residues of HIV-1 gp41 envelope glycoprotein. HA2 peptide adopts a random coil structure under physiological pH conditions; in acidic endosomes, protonation of carboxyl groups reduces negative charge, inducing a transition to an α-helical conformation that can fuse with and destabilize the endosomal membrane. After binding to membranes, the N-terminal and middle regions of HA2 peptide mainly adopt a β-strand conformation, while the C-terminal region remains unstructured. HA2 peptide induces lipid mixing and promotes aqueous content leakage from large unilamellar vesicles whose lipid composition matches that of HIV-1 viruses and target T cells. HA2 peptide is anionic and can bind to cationic peptides to achieve siRNA condensation. HA2 peptide can be used in studies related to cancer and human immunodeficiency virus (HIV) infection .
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Guanidine-13C hydrochloride
Guanidine-13C hydrochloride
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Cat. No.: HY-B0178AS2
CAS No.: 286013-04-5
Synonyms: Guanidinium-13C chloride; Aminoformamidine-13C hydrochloride
Guanidine-13C hydrochloride (Guanidinium-13C chloride) is the 13C-labeled Guanidine hydrochloride (HY-B0178A). 6M Guanidine hydrochloride Solution (6M Guanidinium chloride Solution) is a strong protein denaturant. Guanidine hydrochloride is a strong protein denaturant. Guanidine hydrochloride causes proteins to assume a random coil conformation .
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PQK7
PQK7
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Cat. No.: HY-P11908
Target:  

α-synuclein Apoptosis Reactive Oxygen Species (ROS)

Research Areas:  

Neurological Disease

PQK7 is an α-synuclein (α-synuclein) binder with a Kd value of 4 μM. PQK7 binds to key residues in the NAC region of ⍺-Syn, enhances the fluctuation of ⍺-Syn, reduces β-sheet content, maintains the solubility of ⍺-Syn monomers, and preserves the normal function of the protein. PQK7 reduces the toxicity of ⍺-Syn aggregates, restores cell cycle progression, decreases apoptosis (apoptosis), and inhibits ROS production. PQK7 can be used for the research of Parkinson's disease .
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DSPE-PEG1000-GALA
DSPE-PEG1000-GALA
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Cat. No.: HY-182098
DSPE-PEG1000-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG1000-GALA can be used for drug delivery .
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DSPE-PEG2000-GALA
DSPE-PEG2000-GALA
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Cat. No.: HY-182098A
DSPE-PEG2000-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG2000-GALA can be used for drug delivery .
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DSPE-PEG3400-GALA
DSPE-PEG3400-GALA
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Cat. No.: HY-182098B
DSPE-PEG3400-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG3400-GALA can be used for drug delivery .
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DSPE-PEG5000-GALA
DSPE-PEG5000-GALA
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Cat. No.: HY-182098C
DSPE-PEG5000-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG5000-GALA can be used for drug delivery .
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