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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
rat OX1R
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "rat OX1R" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: Hypocretin-1 (human, rat, mouse)
Target:
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12
12 Publications Verification
Cat. No.: HY-106224B
Purity: 99.93%
Synonyms: Hypocretin-1 (human, rat, mouse) acetate
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12
12 Publications Verification
Cat. No.: HY-106224A
Purity: 97.13%
Synonyms: Hypocretin-1 (human, rat, mouse) TFA
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2
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Cat. No.: HY-147403S
CAS No.: 1637681-55-0
Synonyms: JNJ-61393215
Synonyms: ACT-539313
Research Areas:
Nivasorexant (ACT-539313) is an orally active, blood-brain barrier penetrant, selective orexin OX1R inhibitor. Nivasorexant specifically blocks central OX1Rs without affecting OX2Rs, and exhibits competitive inhibitory activity against CYP2C8, CYP2C9, CYP2C19 and CYP3A4 (IC50 values are 25 μM, 8.6 μM, 1.6 μM, 19 μM/44 μM, respectively). Nivasorexant significantly reduces binge-like eating behavior of highly palatable food in rat models and has long-acting properties. Nivasorexant shows no relevant off-target activity against over 130 selected proteins, exhibits favorable safety profiles, and can be used for studies related to binge eating disorder .
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MK-3697 is an orally active orexin 2 receptor (OX2R) antagonist, with an IC50 value of 16 nM and a Ki value of 1.1 nM against human OX2R. MK-3697 blocks the wake-promoting OX2R signaling pathway, reduces active wake time, and increases slow-wave sleep and rapid eye movement sleep time in mice, rats and dogs. MK-3697 can be used for research on insomnia .
Cat. No.: HY-106224AS1
Synonyms: Hypocretin-1-13C18,15N3 (human, rat, mouse) TFA
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Cat. No.: HY-184879
CAS No.: 1628320-31-9
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Orexin 1 receptor modulator-1 is a highly potent and selective modulator of the orexin 1 receptor (OX1R), with a Ki value of 4 nM for both rat OX1R and human OX1R, and a Ki value of 767 nM for human OX2R. Orexin 1 receptor modulator-1 can be used in studies related to the orexin signaling pathway and the nervous system .
Cat. No.: HY-106224AS
Synonyms: Hypocretin-1-13C6,15N (human, rat, mouse) TFA
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
