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Cat. No.: HY-184879

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Orexin 1 receptor modulator-1

Orexin 1 receptor modulator-1 is a highly potent and selective modulator of the orexin 1 receptor (OX1R), with a K_i value of 4 nM for both rat OX1R and human OX1R, and a K_i value of 767 nM for human OX2R. Orexin 1 receptor modulator-1 can be used in studies related to the orexin signaling pathway and the nervous system.

For research use only. We do not sell to patients.

CAS No.: 1628320-31-9
Formula: C₂₃H₁₈F₄N₄O₂
Molecular Weight:458.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Orexin 1 receptor modulator-1 Chemical Structure

CAS No.: 1628320-31-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

OX₁ Receptor

4 nM (Ki, human, mice)

human OX2R

767 nM (Ki)

All Orexin Receptor (OX Receptor) Isoforms :

In Vitro

Orexin 1 receptor modulator-1 (compound 27) (0.1 nM-10 μM; 60 min) binds to rat OX1R and human OX1R in competitive radioligand binding assays, with a K_i value of 4 nM for both, and binds to human OX2R with a K_i value of 767 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1628320-31-9
Molecular Weight 458.41
Formula C₂₃H₁₈F₄N₄O₂
SMILES

O=C(C1=C(C2=NC=CC=N2)C(F)=CC=C1)N3[C@]4([H])[C@@H](C[C@@](C3)([H])C4)OC5=CC=C(C=N5)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gelin CF, et al. Substituted 2-azabicycles and their use as orexin receptor modulators. WO2014165070A1. World Intellectual Property Organization. 2014 Oct 9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Orexin 1 receptor modulator-1

All Orexin Receptor (OX Receptor) Isoforms