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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
stable intermediate
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "stable intermediate" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-W591424
CAS No.: 92451-01-9
Synonyms: mPEG2000-SC; mPEG2000-Succinimidyl ester
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Biotin-TEG-ATFBA is a click chemistry reagent containing a perfluorophenylazide group. Biotin-TEG-ATFBA forms a highly stable azene intermediate that undergoes insertion and addition reactions (non-intermolecular rearrangement) in moderate to good yields after photolysis. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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BLI-489 hydrate is a Beta-lactamase inhibitor. BLI-489 hydrate is an antibacterial adjuvant that significantly enhances the antibacterial efficacy of β-lactam antibiotics. BLI-489 hydrate blocks the hydrolytic activity of the enzyme by forming a stable intermediate in serine Beta-lactamase, or by coordinating with the binuclear Zn 2+ through an oxygen atom in metallo-Beta-lactamase. BLI-489 hydrate can be used for research on bacterial infections .
Cat. No.: HY-W002718
CAS No.: 16063-69-7
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2,4,6-Trichloropyridine is a trichloro-substituted nitrogen-containing heterocyclic compound that serves as an intermediate for studies related to organic synthesis. 2,4,6-Trichloropyridine reacts with n-BuLi to form a stable 3-lithiated pyridine intermediate .
Cat. No.: HY-44087
CAS No.: 54716-02-8
Cat. No.: HY-21286
CAS No.: 63264-29-9
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N2-Isobutyryl-2'-O-methylguanosine is a nucleic acid synthesis intermediate (e.g., used in antisense oligonucleotides, mRNA modification), for example, it is a key monomer for the synthesis of 2'-O-methyl oligoribonucleotides. N2-Isobutyryl-2'-O-methylguanosine enables the final product to form stable double strands with complementary RNA and is not easily degraded by nucleases. N2-Isobutyryl-2'-O-methylguanosine is mainly used in molecular biology research, and can be used to prepare RNA hybridization probes or participate in related biochemical research such as pre-mRNA splicing mechanisms .
Cat. No.: HY-W097018
CAS No.: 76801-93-9
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Iomeprol intermediate-1 (compound 5) is an iodinated polysaccharide compound used in the synthesis of contrast agents. The amino group of Iomeprol intermediate-1 can be coupled to the carboxyl group of the D-glucuronide subunit of non-animal stable hyaluronic acid (NASHA), providing a water-soluble, radiopaque moiety .
Cat. No.: HY-W131302
CAS No.: 5657-17-0
Synonyms: N,N-Ethylenediglycine
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Ethylenediaminediacetic acid (N,N-Ethylenediglycine) is a diamino carboxylic acid and substituted aminoacetic acid that is found as an intermediate in the synthesis of EDTA. Ethylenediaminediacetic acid forms a stable copper (II) chelate that migrates as a characteristic band during paper electrophoresis. Ethylenediaminediacetic acid is convertible to the colorless ketopiperazine U-KP .
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BLI-489 is a Beta-lactamase inhibitor. BLI-489 is an antibacterial adjuvant that significantly enhances the antibacterial efficacy of β-lactam antibiotics. BLI-489 blocks the hydrolytic activity of the enzyme by forming a stable intermediate in serine Beta-lactamase, or by coordinating with the binuclear Zn 2+ through an oxygen atom in metallo-Beta-lactamase. BLI-489 can be used for research on bacterial infections .
Cat. No.: HY-D2902
CAS No.: 2080332-70-1
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Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
SNOTRAP (SNO trapping by triaryl phosphine) is a chemical probe used for detecting S-nitrosylated (SNO) proteins. SNOTRAP selectively converts S-nitrosylated cysteines in proteins into stable disulfide-iminophosphorane intermediates, which are then enriched with streptavidin and detected by nanoLC-MS/MS. SNOTRAP enables global enrichment and label-free quantification of SNO proteins and their modification sites in complex biological samples such as mouse brain tissues. SNOTRAP can be applied to studies related to nitrosative stress-associated diseases, including neurodegenerative diseases, cancer, and multiple sclerosis .
Cat. No.: HY-W004616
CAS No.: 610-92-4
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2,5-Dihydroxyterephthalic acid is a carboxylic acid ligand with antioxidant properties, which serves as a building block for Zn 2+-based metal-organic frameworks (MOFs). 2,5-Dihydroxyterephthalic acid forms stable coordination bonds with transition metal ions, inhibits metal center-water coordination to prevent MOF fluorescence quenching, and enhances the hydrophilicity of MOFs. 2,5-Dihydroxyterephthalic acid acts as a pharmaceutical intermediate to synthesize 2,5-dihydroxyterephthalamide derivatives. 2,5-Dihydroxyterephthalic acid is applicable to relevant research in fields such as organic synthesis .
Cat. No.: HY-W097018R
CAS No.: 76801-93-9
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Iomeprol intermediate-1 (Standard) is the analytical standard of Iomeprol intermediate-1. This product is intended for research and analytical applications. Iomeprol intermediate-1 (compound 5) is an iodinated polysaccharide compound used in the synthesis of contrast agents. The amino group of Iomeprol intermediate-1 can be coupled to the carboxyl group of the D-glucuronide subunit of non-animal stable hyaluronic acid (NASHA), providing a water-soluble, radiopaque moiety .
Cat. No.: HY-176893
CAS No.: 2410723-30-5
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Mm-C3-OSu (Methyl Maleate-C3-N-Hydroxysuccinimide Ester) is a structurally defined linker intermediate with a cis-configured methyl maleate (Mm) core and a C3 alkyl chain terminated by an N-hydroxysuccinimide (OSu) reactive group, designed for constructing stable antibody-drug conjugates (ADCs).
Cat. No.: HY-I0169R
CAS No.: 196601-69-1
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(R)-Amino-N-benzyl-3-methoxypropionamide (Standard) is the analytical standard of (R)-Amino-N-benzyl-3-methoxypropionamide. This product is intended for research and analytical applications. (R)-Amino-N-benzyl-3-methoxypropionamide is a stable intermediate of Lacosamide (an antiepileptic drug) .
Cat. No.: HY-W205529
CAS No.: 87235-61-8
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RO 16-6491 Free base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), exhibiting high affinity and specificity for binding sites in human frontal cortex mitochondria and platelet membranes. RO 16-6491 demonstrates a fast dissociation of bound radioactivity at 20 degrees C, indicating its dynamic binding properties. RO 16-6491 also acts as a substrate for MAO-B, suggesting that its oxidation may produce a stable intermediate responsible for its potent inhibitory effects. RO 16-6491 serves as an excellent radioligand probe for investigating the regional tissue distribution of MAO-B in various physiological and pathological states.
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Neotetrazolium chloride is a photoreducible tetrazolium dye. Neotetrazolium chloride undergoes photoreduction to form a stable red monoformazan via a transient tetrazolinyl radical-tetrazolium intermediate upon UV exposure. Neotetrazolium chloride can be as a UV dosimeter .
Cat. No.: HY-184369
CAS No.: 63146-74-7
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Fluoprazolam (Compound IV) is an unstable oily intermediate. Fluoprazolam is generated via cyclization of N-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl) glycine (IIIa) and rapidly undergoes condensation to form stable derivatives .
Cat. No.: HY-186235
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3-Hydroxydecanoyl-NAC is a substrate mimetic of the bacterial fatty acid biosynthetic pathway, and exhibits activity against FabA and FabG of Pseudomonas aeruginosa. 3-Hydroxydecanoyl-NAC acts as a stable mimetic of acyl carrier protein-linked fatty acids, which are key intermediates in the bacterial FASII pathway. 3-Hydroxydecanoyl-NAC serves as a substrate for Pseudomonas aeruginosa FabA, enabling the measurement of the dehydration activity of this enzyme .
Cat. No.: HY-108062B
CAS No.: 635322-76-8
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BLI-489 free base is a Beta-lactamase inhibitor. BLI-489 free base is an antibacterial adjuvant that significantly enhances the antibacterial efficacy of β-lactam antibiotics. BLI-489 free base blocks the hydrolytic activity of the enzyme by forming a stable intermediate in serine Beta-lactamase, or by coordinating with the binuclear Zn 2+ through an oxygen atom in metallo-Beta-lactamase. BLI-489 free base can be used for research on bacterial infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
