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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
synucleinopathies
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "synucleinopathies" in MCE Product Catalog:
Synonyms: ASN90
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Research Areas:
Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase (OGA) enzyme inhibitor with an IC50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and α-synuclein, preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex). Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies (e.g., Alzheimer’s disease and Parkinson’s disease) .
Cat. No.: HY-170035
CAS No.: 95119-86-1
Synonyms: C18 Glucosyl(β) ceramide (d18:1/18:0); D-glucosyl-β-1,1' N-stearoyl-D-erythro-sphingosine
GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a glycosphingolipids that activates the Wnt/β-catenin pathway by targeting LRP6. GlcCer (d18:1/18:0) drives EMT, migration, invasion and GBA1-mediated liver cancer metastasis. GlcCer (d18:1/18:0) accumulates to impair lysosomal function and induce toxic α-synuclein aggregation. GlcCer (d18:1/18:0) supports growth, sporulation, germination and virulence in Penicillium digitatum. GlcCer (d18:1/18:0) is reduced in demyelinated mouse corpus callosum. GlcCer (d18:1/18:0) can be used for the research of liver cancer, synucleinopathies, fungal, Parkinson’s disease and Gaucher disease .
Cat. No.: HY-160426
CAS No.: 2270984-21-7
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Gcase activator 3 (compound 9Q) is a glucosidase (Glucosidase, GCase) activator that can partially stabilize GCase and increase its activity. Gcase activator 3 reduces mutant GCase protein misfolding and degradation in fibroblasts and dopaminergic midbrain neurons. Gcase activator 3 can be used in the study of Parkinson's disease (PD) and related synucleinopathies .
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YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies .
Cat. No.: HY-163739
CAS No.: 951131-13-8
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LETC is an orally active α-synuclein (α-Syn) aggregation inhibitor with an EC50 of 66 nM in transfected DH60.21 neuroblastoma cells. LETC can cross the blood-brain barrier. LETC can be used for the study of synucleinopathies .
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WAY-309236 is an active molecule for the study of amyloid diseases and synucleinopathies.
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WAY-311474 is an active molecule for research into amyloid diseases and synucleinopathies.
Cat. No.: HY-W436420
CAS No.: 1005086-69-0
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WAY-299375 is an active molecule for research into amyloid diseases and synucleinopathies.
Cat. No.: HY-W674257
CAS No.: 42310-54-3
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WAY-658674 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-W674612
CAS No.: 404360-27-6
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WAY-297848 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-W674624
CAS No.: 620570-09-4
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WAY-312858 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-W793473
CAS No.: 312607-68-4
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WAY-301398 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-47596
CAS No.: 300809-10-3
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WAY-612453 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-47599
CAS No.: 643042-43-7
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WAY-639418 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-47600
CAS No.: 854135-42-5
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WAY-323756 is an active molecule for research into amyloid diseases and synucleinopathies.
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WAY-622252 is an active molecule for the study of amyloid diseases and synucleinopathies.
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WAY-385995 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-49458
CAS No.: 149045-58-9
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WAY-232897 is an active molecule for the study of amyloid diseases and synucleinopathies.
Cat. No.: HY-49460
CAS No.: 796059-20-6
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WAY-639299 is an active molecule for research into amyloid diseases and synucleinopathies.
Cat. No.: HY-49601
CAS No.: 957511-97-6
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WAY-329738 is an active molecule for research into amyloid diseases and synucleinopathies.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
