9 Results for "

tubulointerstitial

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "tubulointerstitial" in MCE Product Catalog:

Cat. No.: HY-P990608
CAS No.: 2921676-05-1
Synonyms: IMC 3C5; JNJ-69086420 antibody; Anti-KLK2 Antibody (h11B6)

Target:  

CD3

Research Areas:  

Endocrinology Cancer

Alpitatug (IMC 3C5) is a fully human monoclonal antibody and also a VEGFR3 inhibitor. Alpitatug blocks renal lymphangiogenesis, prevents the formation of tubulointerstitial lymphatic vessels, and reduces the number of lymphatic vessels in rats. Alpitatug does not alter the proteinuria level, inflammatory cell infiltration, fibrosis markers or renal function parameters in proteinuric rats. Alpitatug can be used in research related to proteinuric nephropathy and advanced solid tumors .
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Cat. No.: HY-13706A
CAS No.: 627865-18-3
Purity:  ≥95.0%
Synonyms: TM30089
Research Areas:  

Inflammation/Immunology

CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. CAY10471 attenuates the progression of tubulointerstitial fibrosis and chronic contact hypersensitivity (CHS) in animal model .
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Cat. No.: HY-Y0308D
CAS No.: 7558-79-4
Synonyms: Disodium hydrogen phosphate, meets analytical specification of Ph. Eur. BP USP FCC E339
Sodium phosphate dibasic (Disodium hydrogen phosphate), meets analytical specification of Ph. Eur. BP USP FCC E339 is an inorganic dibasic phosphate that functions as an electrolyte supplement, a buffer carrier for injectable drugs, while also exhibiting nephrotoxicity. Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339 induces extensive nephrotic syndrome-like changes, including systemic symptoms such as persistent proteinuria, lipemia, hypercholesterolemia, and anemia, and causes severe renal pathological alterations such as renal enlargement, glomerular calcification, podocyte injury, and tubulointerstitial lesions. Sodium phosphate dibasic, meets analytical specification of Ph. Eur. BP USP FCC E339 has the ability to induce phosphate-induced nephropathy and glomerular calcification, and can be widely used in studies on nephrotic syndrome and related renal pathological mechanisms .
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Cat. No.: HY-120268A
CAS No.: 1897379-34-8
Purity:  99.1%
Target:  

SphK

Research Areas:  

Inflammation/Immunology

SLM6031434 hydrochloride is the hydrochloride salt form of SLM6031434 (HY-120268). SLM6031434 is a highly selective sphingosine kinase 2 (SphK2) inhibitor with an IC50 value of 0.4 μM for SphK2. SLM6031434 exerts anti-fibrotic effects by increasing sphingosine accumulation and Smad7 expression. SLM6031434 demonstrates effective anti-fibrotic efficacy in a unilateral ureteral obstruction (UUO)-induced tubulointerstitial fibrosis mouse model. SLM6031434 can be used for the study of proteinuric kidney diseases or chronic kidney disease (CKD) .
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Cat. No.: HY-N10359
CAS No.: 4176-96-9
Isoandrographolide is an orally active NLRP3 inflammasome inhibitor and AKT/GSK-3β/β-catenin pathway inhibitor. Isoandrographolide inhibits the expression of NLRP3, ASC, and caspase-1, and reduces the levels of phosphorylated AKT, phosphorylated GSK-3β, and β-catenin. Isoandrographolide alleviates inflammatory responses, reduces collagen deposition, suppresses epithelial-mesenchymal transition (EMT), induces differentiation of leukemia cells, inhibits the growth of leukemia cells, protects lung and kidney tissues, regulates cytokine levels, and also exhibits hepatoprotective effects. Isoandrographolide can be used in studies related to silicosis, murine myeloid leukemia, renal tubulointerstitial fibrosis, and non-alcoholic fatty liver disease .
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Cat. No.: HY-W134312
CAS No.: 813-94-5
Synonyms: Tricalcium dicitrate
Calcium citrate,AR,99% (Tricalcium dicitrate) is an alkalinizing agent. Calcium citrate,AR,99% attenuates tubulointerstitial damage. Calcium citrate,AR,99% ameliorates the progression of chronic renal injury .
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Cat. No.: HY-120268
CAS No.: 1897379-33-7
Target:  

SphK

Research Areas:  

Inflammation/Immunology

SLM6031434 is a highly selective sphingosine kinase 2 (SphK2) inhibitor with an IC50 value of 0.4 μM for SphK2. SLM6031434 exerts anti-fibrotic effects by increasing sphingosine accumulation and Smad7 expression. SLM6031434 demonstrates effective anti-fibrotic efficacy in a unilateral ureteral obstruction (UUO)-induced tubulointerstitial fibrosis mouse model. SLM6031434 can be used for the study of proteinuric kidney diseases or chronic kidney disease (CKD) .
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Cat. No.: HY-174913
CAS No.: 1644670-23-4
Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy .
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Cat. No.: HY-P71369
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TINAGL1; Lipocalin 7; Prev. LCN7; OLRG-2; TINAGRP; tubulointerstitial Nephritis Antigen-Like 1, Isoform CRA_a; P3ECSL; Oxidized LDL-Responsive Gene 2 Protein; LIECG3; Oxidized-LDL Responsive Gene 2; ARG1; Androgen Regulated Gene 1; tubulointerstitial Neph
Species:  
Source:  
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