FZD8 - frizzled class receptor 8 Gene

Also Known as FZ-8; hFZ8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8325

About FZD8

Cytogenetic location: 10p11.21 Genomic coordinates (GRCh38): 10:35,638,247-35,642,296 (from NCBI)

This gene has 1 transcript (splice variant), 221 orthologues and 15 paralogues.

Summary

This intronless gene is a member of the Frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human Cancer cell lines, indicating that it may play a role in several types of Cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

FZD8 Products (1)

mRNA Protein Name
NM_031866.3 NP_114072.1 frizzled-8 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
18256285 GOA
enables Wnt receptor activity IDA
IDA: Inferred from direct assay
28733458 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22682250 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
22575959 GOA
Biological Process GO Annotation Evidence References Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
28733458 GOA
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
22138402 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD8 Protein Structure

Fz

Fz: Fz domain (35 - 149)

Frizzled

Frizzled: Frizzled/Smoothened family membrane region (267 - 622)

  • 0
  • 200
  • 400
  • 600
  • 694 a.a.
Protein Preferred Names Protein Names

frizzled-8

  • frizzled 8, seven transmembrane spanning receptor

FZD8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
FZD8 Q9H461 C1qa Mus musculus P98086
Pull Down
22682250
Intra
FZD8 Q9H461 WNT3A Homo sapiens P56704
Pull Down
22682250
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FZD8 Proteins

Cat. No. Product Name Accession Purity
HY-P70915 Frizzled-8 Protein, Human (HEK293, His) Q9H461 (A28-P172) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72372 Frizzled-8 Protein, Human (Biotinylated, HEK293, His-Avi) Q9H461 (A28-P172) ≥ 95%, as determined by reducing SDS-PAGE.

FZD8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82307 Frizzled 8 Antibody (YA2052) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Cystitis

  • Infective Cystitis

  • Urocystitis

  • Pyocystitis
Interstitial Cystitis

  • Bladder Pain Syndrome

  • Painful Bladder Syndrome

  • Ulcerative Cystitis

  • Ic/Bps

  • Ic/Pbs

  • Interstitial Cystitis/Bladder Pain Syndrome

  • Interstitial Cystitis/Painful Bladder Syndrome

  • Cystitis, Interstitial

  • Chronic Interstitial Cystitis

  • Pelvic Congestion Syndrome

  • Trigonitis
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Norrie Disease

  • Atrophia Bulborum Hereditaria

  • Episkopi Blindness

  • Pseudoglioma

  • ND

  • Norrie-Warburg Disease

  • Anderson-Warburg Syndrome

  • Fetal Iritis Syndrome

  • Norrie Syndrome

  • Norrie-Warburg Syndrome

  • Ndp

  • Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

  • Norrie'S Disease

  • Oligophrenia Microphthalmus

  • Pseudoglioma Congenita

  • Whitnall-Norman Syndrome
Exudative Vitreoretinopathy

  • Familial Exudative Vitreoretinopathy

  • Fevr

  • Criswick-Schepens Syndrome

  • Exudative Vitreoretinopathy, Familial

  • Vitreoretinopathy, Exudative )

  • Exudative Vitreoretinopathy 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99667 Ipafricept Inhibitor 99.80% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05184 FZD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18477 Fzd8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24958 Fzd8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FZD8 RGD RGD:1560525
Bos taurus FZD8 VGNC VGNC:57008
Felis catus FZD8 VGNC VGNC:82431
Mus musculus FZD8 MGD MGI:108460
Macaca mulatta FZD8 VGNC VGNC:72838
Canis familiaris FZD8 VGNC VGNC:110465
Others FZD8 NCBI