Complement C1q A-Chain (C1QA)
C1QA encodes the A-chain of C1q, the recognition subunit of the C1 complex that initiates the classical complement pathway. C1q assembles from six copies each of the A, B and C chains into a bouquet of collagen-like triple helices tipped by globular C1q heads; the A-chain contributes to the heads that bind the Fc regions of antigen-bound IgG and IgM, as well as apoptotic cells, C-reactive protein and other danger patterns. C1q is produced mainly by macrophages, dendritic cells and microglia rather than hepatocytes. Humans lacking C1QA develop severe early-onset lupus erythematosus and recurrent infections, highlighting its role in immune-complex and dead-cell clearance.
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Complement C1q A-Chain (C1QA) Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
