2. Membrane Transporter/Ion Channel
  3. Na+/HCO3- Cotransporter
  4. SOAT-IN-2

SOAT-IN-2 is a selective sodium-dependent organic anion transporter (SOAT, SLC10A6) inhibitor. SOAT-IN-2 blocks sodium-dependent cellular uptake of sulfated steroid Dehydroepiandrosterone sulfate (DHEAS, HY-113416). SOAT-IN-2 reduces intracellular estradiol synthesis, DHEA (HY-14650) formation, and DHEAS-stimulated cancer cell proliferation without inducing cytotoxicity. SOAT-IN-2 can be used for the research of breast cancer.

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SOAT-IN-2

SOAT-IN-2 Chemical Structure

CAS No. : 3056727-95-5

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SOAT-IN-2 Related Antibodies

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Description

SOAT-IN-2 is a selective sodium-dependent organic anion transporter (SOAT, SLC10A6) inhibitor. SOAT-IN-2 blocks sodium-dependent cellular uptake of sulfated steroid Dehydroepiandrosterone sulfate (DHEAS, HY-113416). SOAT-IN-2 reduces intracellular estradiol synthesis, DHEA (HY-14650) formation, and DHEAS-stimulated cancer cell proliferation without inducing cytotoxicity. SOAT-IN-2 can be used for the research of breast cancer[1].

In Vitro

SOAT-IN-2 (compound 12) (10 μM; 5 min preincubation) potently inhibits sodium-dependent SOAT-mediated [3H]DHEAS uptake in MCF-7_SOAT cells[1].
SOAT-IN-2 (10 μM; 10 min preincubation, 3 days combined treatment with 10 μM DHEAS) completely suppresses DHEAS-stimulated proliferation in MCF-7_SOAT cells[1].
SOAT-IN-2 (10 μM; 30 min preincubation, 72 h combined treatment with 10 μM DHEAS) significantly reduces DHEAS-derived DHEA and estradiol formation in MCF-7_SOAT cells[1].
SOAT-IN-2 inhibits SOAT-mediated DHEAS transport in SOAT-transfected HEK293 cells with an IC50 of 1.9 μM[1].
SOAT-IN-2 (0.1-10 μM; 24 h) is non-cytotoxic to MCF-7_FRT and MCF-7_SOAT cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SOAT-IN-2 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT)
Concentration: 10 μM
Incubation Time: 10 min
Result: Had no effect on MCF-7_SOAT cell proliferation.

Cell Proliferation Assay[1]

Cell Line: SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT)
Concentration: 10 μM plus 10 μM DEHA
Incubation Time: 3 days
Result: Completely abolished the DHEAS-stimulated proliferation of MCF-7_SOAT cells, reducing proliferation to baseline control levels when combined with DHEAS.

Cell Cytotoxicity Assay[1]

Cell Line: SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT), control MCF-7_FRT cells
Concentration: 0.1 μM; 10 μM
Incubation Time: 24 h
Result: Did not induce LDH release in either MCF-7_FRT or MCF-7_SOAT cells, indicating no cytotoxicity under these conditions.
Molecular Weight

500.74

Formula

C19H12Cl3N3O5S
CAS No.
SMILES

O=S(C1=CC=CC([N+]([O-])=O)=C1)(NC2=C(C(NC3=CC(Cl)=C(Cl)C=C3)=O)C=C(Cl)C=C2)=O
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Purity & Documentation
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SOAT-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOAT-IN-23056727-95-5Na+/HCO3- CotransporterNa/HCO3 cotransporterNBCHEK293 cellssodium-dependent organic anion transporterSLC10A6MCF-7_SOAT cellsbreast cancerestradiolDHEASdehydroepiandrosterone sulfateSOATDHEAInhibitorinhibitorinhibit

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