PGR - progesterone receptor Gene

Also Known as PR; NR3C3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5241

About PGR

Cytogenetic location: 11q22.1 Genomic coordinates (GRCh38): 11:101,029,624-101,129,813 (from NCBI)

This gene has 10 transcripts (splice variants), 193 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in endometrium (RPKM 46.4) and ovary (RPKM 5.5).

Summary

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 Amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]

PGR Products (13)

mRNA	Protein	Name
NM_000926.4	NP_000917.3	progesterone receptor isoform B
NR_073142.3
NR_073143.3
NM_001271162.2	NP_001258091.1	progesterone receptor isoform D
NM_001271161.2	NP_001258090.1	progesterone receptor isoform C
NM_001202474.3	NP_001189403.1	progesterone receptor isoform A
XM_006718858.4	XP_006718921.1	progesterone receptor isoform X1
NR_073141.3
XM_011542869.3	XP_011541171.1	progesterone receptor isoform X2
NM_000926.4	NP_000917.3	progesterone receptor isoform B
NM_001202474.3	NP_001189403.1	progesterone receptor isoform A
NM_001271161.2	NP_001258090.1	progesterone receptor isoform C
NM_001271162.2	NP_001258091.1	progesterone receptor isoform D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IDA IDA: Inferred from direct assay	12058073	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17785366	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17785366	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	12039952	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17277083	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	9620806	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1517211	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12771131	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	17015480	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in maintenance of protein location in nucleus	IMP IMP: Inferred from mutant phenotype	20861224	GOA
involved in negative regulation of gene expression	IEP IEP: Inferred from expression pattern	21695196	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17785366	GOA
involved in progesterone receptor signaling pathway	IDA IDA: Inferred from direct assay	9620806	GOA
involved in progesterone receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10757795	GOA
involved in regulation of DNA-templated transcription	EXP EXP: Inferred from Experiment	20861224	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	37478846	GOA
is active in plasma membrane	IMP IMP: Inferred from mutant phenotype	22031296	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGR Protein Structure

Prog_receptor

zf-C4

Hormone_recep

0
200
400
600
800
933 a.a.

Protein Preferred Names	Protein Names
progesterone receptor	nuclear receptor subfamily 3 group C member 3

PGR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PGR	P06401	CUEDC2	Homo sapiens	Q9H467	Pull Down	17347654
Intra	PGR	P06401	CUEDC2	Homo sapiens	Q9H467	Confocal	17347654
Intra	PGR	P06401	CUEDC2	Homo sapiens	Q9H467	Anti Bait CoIP	17347654
Intra	PGR	P06401	CUEDC2	Homo sapiens	Q9H467	Y2H	17347654
Intra	PGR	P06401	CUEDC2	Homo sapiens	Q9H467	Beta Galactosidase	17347654
Intra	PGR	P06401	STAT3	Homo sapiens	P40763	CH-IP	20876300
Intra	PGR	P06401	ESR1	Homo sapiens	P03372	Crosslink	26153859
Intra	PGR	P06401	ESR1	Homo sapiens	P03372	Anti Bait CoIP	26153859
Intra	PGR	P06401	ESR1	Homo sapiens	P03372	CH-IP	22396492
Intra	PGR	P06401	ESR1	Homo sapiens	P03372	Anti Bait CoIP	22396492
Intra	PGR	P06401	ESR1	Homo sapiens	P03372	Confocal	22396492

Cross: Cross-species interaction Intra: Intraspecies interaction

PGR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81991	Phospho-Progesterone Receptor (Ser190) Antibody (YA1736)	WB, IHC-P	Human
HY-P81991A	Phospho-Progesterone Receptor (Ser190) Antibody (YA1736)(PBS only)	WB, IHC-P	Human
HY-P82121	Progesterone Receptor Antibody (YA1866)	WB, IHC-P, ICC/IF, IP	Human
HY-P83972	Progesterone Receptor Antibody (YA3669)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P83972A	Progesterone Receptor Antibody (YA3669)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse
HY-P85965	Progesterone Receptor Antibody (YA5657)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat, Rabbit

Related Diseases

Diseases	Alias
Eccrine Papillary Adenocarcinoma	Digital Papillary Adenocarcinoma Sweat Gland Adenocarcinoma Digital Papillary Eccrine Carcinoma Of Skin
Carcinosarcoma	Mixed Tumor, Mullerian Malignant Mixed Mesodermal Tumor Malignant Mixed Mullerian Tumor Mmmt Mixed Tumor, Mesodermal Mesodermal Mixed Tumor Mixed Mesodermal Tumor Mullerian Mixed Tumor Mixed Mullerian Tumor Malignant Mixed Müllerian Tumor Mixed Müllerian Tumor Mixed Tumor Mullerian Mixed Tumor, Not Otherwise Specified
Subserous Uterine Fibroid	Subserous Leiomyoma Of Uterus
Cervical Benign Neoplasm
Breast Myoepithelial Carcinoma
Ovarian Disease	Ovarian Dysfunction Ovarian Diseases Ovarian Disorders Disorder Of Endocrine Ovary
Vagina Leiomyosarcoma	Leiomyosarcoma Of The Vagina Vaginal Leiomyosarcoma
Cystadenocarcinoma
Endometrial Hyperplasia
Oropharynx Cancer	Oropharyngeal Cancer Oropharyngeal Carcinoma Malignant Neoplasm Of Oropharynx Malignant Oropharyngeal Tumor Malignant Tumor Of Oropharynx Malignant Tumour Of Mesopharynx Oropharyngeal Cancer, Adult Cancer Of The Oropharynx
Ovarian Papillary Neoplasm	Ovarian Papillary Tumor Ovarian Papillary Tumour Papillary Tumor Of Ovary
Urethral Benign Neoplasm	Urethral Neoplasms Neoplasm Of Urethra Neoplasm. Urethra Urethral Neoplasm Urethral Carcinoma Malignant Neoplasm Of Urethra
Cervical Polyp	Cervix Adenomatous Polyp
Sclerosing Hemangioma	Sclerosing Haemangioma Cutaneous Fibrous Histiocytoma
Scirrhous Adenocarcinoma	Adenocarcinoma, Scirrhous Adenocarcinoma With Productive Fibrosis
Middle Cranial Fossa Meningioma	Meningioma Of The Middle Cranial Fossa
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Her2-Receptor Negative Breast Cancer
Uterine Corpus Cancer	Corpus Uteri Cancer Malignant Uterine Corpus Neoplasm
Cervical Serous Adenocarcinoma
Ovarian Serous Adenofibroma
Aromatase Excess Syndrome	AEXS Increased Aromatase Activity Familial Hyperestrogenism Hereditary Prepubertal Gynecomastia Aromatase Activity, Increased Familial Gynecomastia Due To Increased Aromatase Activity Hereditary Gynecomastia Gynecomastia, Familial Familial Gynecomastia
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Granulomatous Endometritis
Sporadic Breast Cancer	Sporadic Breast Carcinoma
Disorder Of Sexual Development	Disorder Of Sex Development Sex Development Disorder Sex Differentiation Disease Dsd Disorders Of Sex Development Sex Differentiation Disorders
Prolapse Of Urethra	Urethrocele
Intravenous Leiomyomatosis	Leiomyomatosis
Bartholin'S Gland Benign Neoplasm	Bartholin Gland Neoplasm Tumor Of Bartholin'S Gland Bartholin'S Gland Carcinoma
Intracystic Papillary Adenoma	Intracystic Papilloma
Peritoneal Benign Neoplasm
Vagina Sarcoma	Sarcoma Of The Vagina Vaginal Sarcoma
Polyp Of Corpus Uteri	Endometrial/Uterine Polyp Polyp Of Endometrium Polyp Of The Uterus Polyp, Uterus
Lung Meningioma	Lung Primary Meningioma Primary Pulmonary Meningioma Pulmonary Meningioma Primary Lung Meningioma
Cerebral Meningioma	Meningioma Of Cerebrum
Pulmonary Vein Leiomyosarcoma	Leiomyosarcoma Of The Pulmonary Vein
Progesterone-Receptor Positive Breast Cancer
Olfactory Groove Meningioma	Meningioma Of The Olfactory Groove
Tonsil Cancer	Tonsillar Neoplasms Malignant Neoplasm Of Faucial Tonsil Malignant Neoplasm Of Palatine Tonsil Malignant Neoplasm Of Tonsil, Faucial Malignant Tonsillar Tumor Malignant Tumor Of Tonsil Tonsillar Carcinoma Malignant Neoplasm Tonsil
Lipid-Rich Breast Carcinoma
Trabecular Follicular Adenocarcinoma	Follicular Adenocarcinoma, Trabecular Trabecular Follicular Carcinoma
Estrogen-Receptor Positive Breast Cancer
Comedo Carcinoma	Comedocarcinoma High Grade Ductal Breast Carcinoma In Situ
Inflammatory Breast Carcinoma	Inflammatory Breast Cancer Inflammatory Carcinoma Of Breast Mastitis Carcinomatosa Breast Cancer, Inflammatory Inflammatory Breast Neoplasms Inflammatory Adenocarcinoma Of Breast
Spinal Canal And Spinal Cord Meningioma
Prostate Sarcoma	Sarcoma Of The Prostate
Lung Leiomyoma	Pulmonary Leiomyoma Leiomyoma Of Lung
Hepatitis E
Vaginal Endometrial Stromal Sarcoma
Tubular Adenocarcinoma	Tubular Carcinoma Adenocarcinoma Tubular Adenocarcinoma, Tubular
Myoma	Muscle Benign Neoplasm Myomatous Neoplasm Neoplasms, Muscle Tissue Benign Neoplasm Of The Muscle Muscle Neoplasm Muscle Tissue Neoplasm Myomatous Tumor Neoplasm Of Muscle Muscle Neoplasms Myomas
Sweat Gland Benign Neoplasm	Neoplasm Of Sweat Gland Sweat Gland Tumor Tumor Of The Sweat Gland Sweat Gland Neoplasms Sweat Gland Neoplasm
Sweat Gland Disease	Sweat Gland Diseases
Microglandular Adenosis	Breast Fibrocystic Disease Adenosis - Breast Adenosis Of The Breast Fibrocystic Breast Disease Breast Adenosis Adenosis Of Breast
Adult Type Testicular Granulosa Cell Tumor
Breast Duct Papilloma	Intraductal Papilloma Of Breast Duct Papilloma Of Breast Papilloma Of The Breast
Nephroma	Benign Nephroma
Intraductal Breast Benign Neoplasm
Estrogen-Receptor Negative Breast Cancer
Vagina Leiomyoma	Leiomyoma Of Vagina
Ovarian Seromucinous Carcinoma	Mixed Epithelial Carcinoma Of Ovary Ovary Mixed Epithelial Carcinoma
Fibroma
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
In Situ Carcinoma	Carcinoma In Situ
Breast Granular Cell Tumor
Adhesions Of Uterus	Intrauterine Adhesions Intrauterine Synechiae Band Of Uterus Asherman Syndrome Internal Adhesion Of Uterus Internal Band Of Uterus
Adenosquamous Carcinoma	Adenosquamous Cell Carcinoma Mixed Adenocarcinoma And Squamous Carcinoma Carcinoma Adenosquamous Carcinoma, Adenosquamous
Skull Base Cancer	Tumors Of Skull Base Skull Base Neoplasms
Oncocytic Breast Carcinoma
Hemangioma	Hemangiomas
Glycogen-Rich Clear Cell Breast Carcinoma	Glycogen-Rich Carcinoma
Endometrial Disease	Endometrial Disorder Endometrial Diseases
Ovary Adenocarcinoma	Ovarian Adenocarcinoma Adenocarcinoma Of The Ovary Ovarian Adenoacanthoma Adenocarcinoma Of Ovary
Uterus Interstitial Leiomyoma	Intramural Leiomyoma Of Uterus
Sublingual Gland Adenoid Cystic Carcinoma
Breast Cystic Hypersecretory Carcinoma	Cystic Hypersecretory Carcinoma Of The Breast Cystic Hypersecretory Duct Carcinoma Of The Breast
Ovarian Cyst	Ovarian Cysts
Urethral Villous Adenoma
Endometrial Serous Adenocarcinoma	Uterine Corpus Serous Adenocarcinoma Uterine Papillary Serous Carcinoma Uterine Serous Carcinoma
Pyometritis
Breast Carcinoma In Situ	Carcinoma In Situ Of Breast Non-Infiltrating Carcinoma Of Breast Breast Cancer In Situ
Cervical Adenomyoma
Sertoli-Leydig Cell Tumor	Sertoli-Leydig Cell Tumors Androblastoma Of Ovary Arrhenoblastoma Arrhenoblastoma Of Ovary Sertoli-Leydig Cell Tumor Of The Ovary Sertoli-Leydig Cell Tumor Of Intermediate Differentiation Sertoli-Leydig Cell Tumor Of Ovary
Lipid-Rich Carcinoma
Uterus Leiomyosarcoma	Leiomyosarcoma Of Uterus Leiomyosarcoma Of Corpus Uteri Leiomyosarcoma Of The Corpus Uteri Uterine Leiomyosarcoma
Breast Abscess	Abscess Of Breast
Hypertrophy Of Breast	Breasts Enlarged Large Breast Hypertrophy Of Breast Nos Hypertrophy Of Male Breast Hypertrophic Breast Excessive Development Of Breast Macromastia Mastoplastia
Cervical Adenocarcinoma	Adenocarcinoma Cervix Uteri Adenocarcinoma Of Cervix Adenocarcinoma Of The Uterine Cervix Adenocarcinoma Of The Cervix Uteri
Papillary Serous Adenocarcinoma	Micropapillary Serous Carcinoma Serous Surface Papillary Carcinoma Papillary Serous Carcinoma Papillary Serous Cystadenocarcinoma
Chronic Tympanitis
Breast Sarcoma	Sarcoma Of Breast
Lymphangioleiomyomatosis	Lymphangiomyomatosis LAM Lung Lymphangioleiomyomatosis Pulmonary Lymphangioleiomyomatosis Lymphangioleiomyomatosis, Somatic Lymphangio-Myomatosis
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Bartholin'S Gland Adenoma	Bartholin Gland Adenoma
Benign Meningioma	Meningioma, Benign
Breast Squamous Cell Carcinoma	Breast Primary Squamous Cell Carcinoma Primary Squamous Cell Carcinoma Of Breast Primary Squamous Cell Carcinoma Of The Breast Scc Of Breast Squamous Cell Carcinoma Of Breast Squamous Cell Breast Carcinoma
Cystadenoma	Cystoma Craniopharyngioma
Psammomatous Meningioma
Breast Mucinous Cystadenocarcinoma
Short Syndrome	Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay Aarskog-Ose-Pande Syndrome Lipodystrophy, Partial, With Rieger Anomaly And Short Stature Lipodystrophy-Rieger Anomaly-Diabetes Syndrome Rieger Anomaly-Partial Lipodystrophy Syndrome Partial Lipodystrophy With Rieger Anomaly And Short Stature Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay Growth Retardation-Rieger Anomaly Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay SHORTS
Mammary Paget'S Disease	Paget'S Disease Mammary Paget Disease Paget'S Disease Of The Breast Paget Disease Of The Breast Paget'S Disease Of The Nipple Paget'S Disease, Mammary Paget Cell Neoplasm Paget Disease Of The Nipple Pagets Disease Mammary Osteitis Deformans
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Pre-Malignant Neoplasm
Smooth Muscle Tumor
Prostate Stromal Sarcoma	Stromal Sarcoma Of The Prostate
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Pancreatic Mucinous Cystadenoma	Pancreatic Mucinous Cystic Neoplasm Pancreatic Mucinous-Cystic Neoplasm
Breast Adenoma	Ademoma - Breast
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Bartholin'S Gland Disease	Bartholin Gland Disease
Cervical Adenosarcoma	Cervical Muellerian Adenosarcoma Cervical Mullerian Adenosarcoma
Gastric Diffuse Adenocarcinoma	Diffuse Gastric Adenocarcinoma Carcinoma, Diffuse Type
Spinal Meningioma	Spinal Cord Meningioma Meningioma, Spine Meningioma Meningioma, Benign, No Icd-O Subtype
Synchronous Bilateral Breast Carcinoma
Thoracic Cancer	Thoracic Tumor Thorax Cancer Thorax Neoplasm Tumor Of Thorax Thoracic Neoplasms
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Premenstrual Tension	Premenstrual Syndrome Pmt - [Premenstrual Tension] Premenstrual Tension Nos Syndrome Of Menstruation
Adenosarcoma	Mullerian Adenosarcoma
Teeth Hard Tissue Disease
Endometritis
Breast Malignant Phyllodes Tumor	Malignant Cystosarcoma Phyllodes Malignant Phyllodes Tumor Of Breast Malignant Phyllodes Tumour Of Breast Phyllodes Breast Tumor Phyllodes Tumor Of The Breast Breast Malignant Phyllodes Tumour Malignant Mammary Phyllodes Tumor Malignant Mammary Phyllodes Tumour Malignant Phyllodes Neoplasm Malignant Phyllodes Tumor Malignant Phyllodes Tumour Phyllodes Breast Neoplasm Phyllodes Breast Tumour Phyllodes Tumor, Malignant Cystosarcoma Phyllodes Cystosarcoma Phyllodes Of The Breast Phylloides Tumor Malignant Breast Phyllodes Tumor Breast Phyllodes Tumor Phyllodes Tumor Malignant Phyllodes Cystosarcoma Of Unspecified Site
Sex Cord-Gonadal Stromal Tumor	Sex Cord Stromal Tumour Sex Cord-Gonadal Stromal Tumour Sex Cord-Stromal Neoplasm Specialized Gonadal Neoplasm Specialized Gonadal Tumor Specialized Gonadal Tumour Sex Cord-Gonadal Stromal Tumors Sex Cord-Stromal Tumor Malignant Testicular Sex Cord-Stromal Tumor Sex Cord Stromal Tumor Of Testis
Breast Fibroadenoma	Fibroadenoma Fibroadenoma Of Breast Juvenile Fibroadenoma Of Breast Cellular Fibroadenoma Complex Fibroadenoma Of Breast Juvenile Fibroadenoma Fibroadenoma Nos Fibroadenoma Unspecified Site
Breast Papillary Carcinoma	Breast Solid Papillary Carcinoma Papillary Carcinoma Of Breast Papillary Carcinoma Of The Breast Solid Papillary Carcinoma Of The Breast
Glycogen-Rich Carcinoma	Doid:0081028
Bilateral Breast Cancer	Bilateral Breast Carcinoma
Endometriosis Of Ovary	Ovarian Endometriosis
Thoracic Benign Neoplasm	Benign Neoplasm Of Thorax
Uterine Corpus Endometrial Carcinoma
Diffuse Peritoneal Leiomyomatosis	Disseminated Peritoneal Leiomyomatosis Leiomyomatosis Peritonealis Disseminata Dpl Lpd Leiomyomatosis Peritonealis Disseminate
Female Breast Cancer	Female Breast Carcinoma Carcinoma Of Female Breast Mammary Carcinoma Of Female Breast Malignant Neoplasm Of Female Breast
Breast Leiomyoma
Cribriform Carcinoma	Ductal Carcinoma, Cribriform Type Carcinoma Cribriform Carcinoma, Cribriform
Leiomyoma, Uterine	Uterine Leiomyoma Uterine Fibroids Uterine Fibroid Plexiform Leiomyoma UL Leiomyoma Of Corpus Uteri Uterus Fibroma
Cervical Mucinous Adenocarcinoma
Breast Adenoid Cystic Carcinoma	Adenoid Cystic Breast Carcinoma Adenoid Cystic Carcinoma Of Breast Mammary Adenocystic Carcinoma
Vulvar Benign Neoplasm
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Vaginal Cancer	Malignant Neoplasm Of Vagina Vaginal Neoplasms Malignant Tumor Of Vagina Malignant Vaginal Tumor Neoplasm Of Vagina Vagina Neoplasm Vaginal Tumor Vaginal Carcinoma Vaginal Malignant Epithelial Tumor Vaginal Neoplasm Malignant Vaginal Neoplasm Vagina Carcinoma Vaginal Neoplasia Cancer Of Vagina Malignant Tumour Of Vagina Carcinoma Of Vagina Primary Malignant Neoplasm Of Vagina Vagina Wall Cancer Vaginal Wall Cancer
Breast Ductal Carcinoma	Ductal Breast Carcinoma Duct Carcinoma Carcinoma, Ductal Mammary Ductal Carcinoma Ductal Carcinoma
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Adenomyoma
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Meningothelial Meningioma	Meningotheliomatous Meningioma
Vulvar Syringoma
Breast Lobular Carcinoma	Cancer, Breast, Lobular Lobular Breast Carcinoma
Progesterone Resistance	Pseudocorpus Luteum Insufficiency
Uterine Benign Neoplasm
Breast Benign Neoplasm	Benign Tumour Of Breast Benign Neoplasm Of Female Breast
Intraductal Papilloma	Papilloma, Intraductal Ductal Papilloma Papilloma Intraductal
Apocrine Adenocarcinoma	Apocrine Carcinoma Apocrine Gland Carcinoma Carcinoma Of The Apocrine Gland Carcinoma Of Apocrine Gland
Breast Disease	Breast Diseases
Liver Leiomyoma	Leiomyoma Of The Liver
Transitional Meningioma	Transitional Meningioma
Ductal Carcinoma In Situ	Noninfiltrating Intraductal Carcinoma
Endocervical Carcinoma	Carcinoma Of Endocervix Carcinoma Of The Endocervix
Uterine Body Mixed Cancer	Malignant Mixed Tumor Of Corpus Uteri Malignant Mixed Tumor, Not Otherwise Specified
Breast Metaplastic Carcinoma	Metaplastic Carcinoma Of The Breast Metaplastic Breast Carcinoma Metaplastic Carcinoma Of Breast Metaplastic Breast Cancer
Cellular Leiomyoma
Triple-Receptor Negative Breast Cancer
Breast Mucinous Carcinoma	Mucinous Carcinoma Of Breast Invasive Mucinous Breast Carcinoma
Vaginal Glandular Tumor	Vaginal Glandular Neoplasm
Serous Cystadenocarcinoma	Serous Adenocarcinoma Cystadenocarcinoma, Serous Serous Carcinoma Cystadenocarcinoma Serous
Leiomyomatosis
Bulbospinal Polio
Leiomyosarcoma	Leiomyosarcomas
Lobular Neoplasia	Lobular Carcinoma In Situ Lobular Carcinoma In Situ Of Breast Lobular Intraepithelial Neoplasia Non-Infiltrating Lobular Carcinoma Noninfiltrating Lobular Carcinoma Unspecified Site Noninfiltrating Lobular Carcinoma Of Breast Lobular Carcinoma In Situ Unspecified Site
Linitis Plastica	Leather-Bottle Stomach
Progesterone-Receptor Negative Breast Cancer
Infertility
Ovarian Serous Cystadenofibroma
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Female Reproductive Endometrioid Cancer	Endometrioid Tumor Endometrioid Neoplasm Female Reproductive Endometrioid Neoplasm
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Childhood Optic Nerve Glioma	Glioma Of The Pediatric Visual Pathway Optic Nerve Glioma, Childhood
Gynecomastia
Sweat Gland Cancer	Sweat Gland Carcinoma Malignant Neoplasm Of Sweat Gland Malignant Tumor Of The Sweat Gland Carcinoma Of The Sweat Gland Primary Malignant Neoplasm Of Sweat Gland Sweat Gland Neoplasms
Intracranial Meningioma	Meningioma
Vulvar Leiomyoma
Endometrial Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Endometrium
Uterine Corpus Adenosarcoma	Adenosarcoma Of Uterine Corpus Uterine Corpus Mullerian Adenosarcoma
Pneumothorax	Pneumothorax Nos Air Leak Nos Pleural Air Leak Nos
Endometrial Stromal Tumor	Endometrial Stromal Neoplasm Endometrial Stromal Tumors
Estrogen Excess	Hyperestrogenism
Vestibular Gland Benign Neoplasm
Endometrial Stromal Sarcoma	Ess Endometrial Stromal Sarcoma, High Grade Undifferentiated Endometrial Sarcoma Stromal Sarcoma Of The Corpus Uteri Sarcoma Endometrial Stromal Sarcoma, Endometrial Stromal Undifferentiated Stromal Sarcoma
Sertoli Cell Tumor	Tubular Androblastoma
Clear Cell Meningioma
External Ear Carcinoma	Carcinoma Of External Ear Carcinoma Of The External Ear
Bizarre Leiomyoma	Atypical Leiomyoma Pleomorphic Leiomyoma Symplastic Leiomyoma
Adult Cystic Nephroma	Multilocular Cystic Nephroma, Mixed Epithelial Stromal Tumour And Renal Epithelial Stromal Tumour
Basaloid Lung Carcinoma	Basaloid Lung Cancer
Angiomyolipoma	Angiomyolipoma Of Kidney
Leiomyoma	Leiomyomatous Neoplasm Leiomyomatous Tumor Leiomyomas Fibroid Tumor Uterine Fibroids
Endocervical Adenocarcinoma	Endocervical Carcinoma
Cervix Carcinoma	Cancer Of Cervix Carcinoma Of Cervix Carcinoma Cervix Uteri Carcinoma Of The Cervix Uteri
Brain Meningioma	Intracranial Meningioma
Papillary Carcinoma	Carcinoma, Papillary Carcinoma Papillary
Fibromuscular Dysplasia
Adenosquamous Breast Carcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Breast Apocrine Carcinoma	Apocrine Carcinoma Of Breast Apocrine Breast Carcinoma
Endometrial Adenocarcinoma	Endometrial Endometrioid Adenocarcinoma Endometrial Adenoacanthoma Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation Adenocarcinoma Of Endometrium Adenocarcinoma Of The Endometrium Adenocarcinoma Of Uterus Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation Endometrioid Adenoma Or Carcinoma Endometrioid Adenomas And Carcinomas Endometrioid Carcinoma Of Endometrium Endometrium Adenocarcinoma
Benign Breast Phyllodes Tumor	Phyllodes Tumor Benign Cystosarcoma Phyllodes Benign Phyllodes Neoplasm Benign Phyllodes Neoplasm Of The Breast Cystosarcoma Phyllodes Phyllodes Neoplasm Phyllodes Tumor, Benign
Apocrine Sweat Gland Neoplasm	Apocrine Tumor Apocrine Neoplasm
Breast Fibroadenosis	Fibroadenosis Of Breast Fibroadenosis - Breast Adenofibrosis Of Breast Fibroadenosis Of Breast Nos
Pregnancy Adenoma	Lactating Adenoma
Mixed Cell Type Cancer	Malignant Mixed Neoplasm Malignant Mixed Tumor Mixed Neoplasm Mixed Tumor, Malignant Malignant Mixed Cancer Mixed Tumor Malignant Mixed Tumor, Not Otherwise Specified Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Reproductive Organ Benign Neoplasm
Vaginal Discharge
Nipple Carcinoma
Spinal Polio

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10396	PGR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10397	Pgr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10398	Pgr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-164997	15-keto Prostaglandin F1α		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PGR	MGD	MGI:97567
Felis catus	PGR	VGNC	VGNC:105833
Canis familiaris	PGR	VGNC	VGNC:44469
Macaca mulatta	PGR	VGNC	VGNC:75972
Bos taurus	PGR	VGNC	VGNC:106863
Rattus norvegicus	PGR	RGD	RGD:3317
Others	PGR	NCBI