CUEDC2 - CUE domain containing 2 Gene

Also Known as C10orf66; bA18I14.5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79004

About CUEDC2

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,423,249-102,432,574 (from NCBI)

This gene has 4 transcripts (splice variants) and 189 orthologues. Ubiquitous expression in brain (RPKM 31.2), heart (RPKM 24.6) and 25 other tissues.

Summary

Predicted to enable ubiquitin binding activity. Acts upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of macrophage cytokine production. Located in cytosol; nuclear membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CUEDC2 Products (1)

mRNA Protein Name
NM_024040.3 NP_076945.2 CUE domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17347654 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
24882011 GOA
acts upstream of or within negative regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
24882011 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUEDC2 Protein Structure

CUE

CUE: CUE domain (149 - 185)

  • 0
  • 100
  • 200
  • 287 a.a.
Protein Preferred Names Protein Names

CUE domain-containing protein 2

CUEDC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CUEDC2 Q9H467 ESR1 Homo sapiens P03372
Pull Down
17347654
Intra
CUEDC2 Q9H467 PGR Homo sapiens P06401
Confocal
17347654
Intra
CUEDC2 Q9H467 PGR Homo sapiens P06401
Anti Tag CoIP
17347654
Intra
CUEDC2 Q9H467 PGR Homo sapiens P06401
Pull Down
17347654
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypertrophy Of Breast

  • Breasts Enlarged

  • Large Breast

  • Hypertrophy Of Breast Nos

  • Hypertrophy Of Male Breast

  • Hypertrophic Breast

  • Excessive Development Of Breast

  • Macromastia

  • Mastoplastia
Myasthenic Syndrome, Congenital, 5

  • Endplate Acetylcholinesterase Deficiency

  • Congenital Myasthenic Syndrome 5

  • CMS5

  • Ead

  • Engel Congenital Myasthenic Syndrome

  • Myasthenic Syndrome, Congenital, Engel Type

  • Cms Ic

  • Congenital Myasthenic Syndrome Type Ic

  • Congenital Myasthenic Syndrome Type Ic, Formerly

  • Cms1c, Formerly

  • Cms Ic, Formerly

  • Congenital Myasthenic Syndrome Engel Type

  • End Plate Acetylcholinesterase Deficiency

  • Synaptic Congenital Myasthenic Syndromes

  • Cms1c

  • Cmse

  • Congenital Myasthenic Syndrome Type 1c

  • End-Plate Acetylcholinesterase Deficiency

  • Myasthenic Syndrome, Congenital, Type 5
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03358 CUEDC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CUEDC2 MGD MGI:1914366
Felis catus CUEDC2 VGNC VGNC:61281
Bos taurus CUEDC2 VGNC VGNC:55945
Canis familiaris CUEDC2 VGNC VGNC:39727
Rattus norvegicus CUEDC2 RGD RGD:1308096
Others CUEDC2 NCBI