RAD21 - RAD21 cohesin complex component Gene

Also Known as MGS; HR21; MCD1; NXP1; SCC1; CDLS4; hHR21; HRAD21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5885

About RAD21

Cytogenetic location: 8q24.11 Genomic coordinates (GRCh38): 8:116,845,934-116,874,776 (from NCBI)

This gene has 21 transcripts (splice variants), 279 orthologues, 2 paralogues and is associated with 82 phenotypes. Ubiquitous expression in bone marrow (RPKM 65.1), lymph node (RPKM 64.2) and 25 other tissues.

Summary

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during Mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]

RAD21 Products (1)

mRNA	Protein	Name
NM_006265.3	NP_006256.1	double-strand-break repair protein rad21 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12672959	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	18499658	GOA
involved in protein localization to chromatin	IMP IMP: Inferred from mutant phenotype	21111234	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19468298	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cohesin complex	IDA IDA: Inferred from direct assay	11590136	GOA
part of mitotic cohesin complex	IPI IPI: Inferred from physical interaction	23242214	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	11590136	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD21 Protein Structure

Rad21_Rec8_N

Rad21_Rec8

0
100
200
300
400
500
600
631 a.a.

Protein Preferred Names	Protein Names
double-strand-break repair protein rad21 homolog	NXP-1

RAD21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAD21	O60216	WAPL	Homo sapiens	Q7Z5K2	Density Sedimentation	17112726
Intra	RAD21	O60216	WAPL	Homo sapiens	Q7Z5K2	Anti Tag CoIP	35271311
Intra	RAD21	O60216	WAPL	Homo sapiens	Q7Z5K2	Anti Bait CoIP	17112726
Intra	RAD21	O60216	WAPL	Homo sapiens	Q7Z5K2	Anti Tag CoIP	26496610
Intra	RAD21	O60216	WAPL	Homo sapiens	Q7Z5K2	Anti Tag CoIP	33961781
Intra	RAD21	O60216	STAG2	Homo sapiens	Q8N3U4	ITC	29263825
Intra	RAD21	O60216	STAG2	Homo sapiens	Q8N3U4	Anti Tag CoIP	35271311
Intra	RAD21	O60216	STAG2	Homo sapiens	Q8N3U4	Cosedimentation	17113138
Intra	RAD21	O60216	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	20818333
Intra	RAD21	O60216	STAG2	Homo sapiens	Q8N3U4	Anti Tag CoIP	33961781
Intra	RAD21	O60216	STAG2	Homo sapiens	Q8N3U4	Anti Tag CoIP	26496610
Intra	RAD21	O60216	PDS5A	Homo sapiens	Q29RF7	Anti Tag CoIP	28514442
Intra	RAD21	O60216	PDS5A	Homo sapiens	Q29RF7	Anti Tag CoIP	26496610
Intra	RAD21	O60216	PDS5A	Homo sapiens	Q29RF7	Anti Tag CoIP	33961781
Intra	RAD21	O60216	PDS5B	Homo sapiens	Q9NTI5	Anti Tag CoIP	33961781
Intra	RAD21	O60216	SSU72	Homo sapiens	Q9NP77	Pull Down	20818333
Intra	RAD21	O60216	SSU72	Homo sapiens	Q9NP77	Anti Tag CoIP	20818333
Intra	RAD21	O60216	SSU72	Homo sapiens	Q9NP77	Anti Bait CoIP	20818333
Intra	RAD21	O60216	FHL3	Homo sapiens	Q13643	Y2H Array	25416956
Intra	RAD21	O60216	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	35271311
Intra	RAD21	O60216	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	20818333
Intra	RAD21	O60216	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	33961781
Intra	RAD21	O60216	SMC1A	Homo sapiens	Q14683	Cosedimentation	17113138
Intra	RAD21	O60216	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	28514442
Intra	RAD21	O60216	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	26496610
Intra	RAD21	O60216	SMC3	Homo sapiens	Q9UQE7	Anti Tag CoIP	35271311
Intra	RAD21	O60216	SMC3	Homo sapiens	Q9UQE7	Cosedimentation	17113138
Intra	RAD21	O60216	SMC3	Homo sapiens	Q9UQE7	Anti Tag CoIP	33961781
Intra	RAD21	O60216	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	20818333
Intra	RAD21	O60216	SMC3	Homo sapiens	Q9UQE7	Anti Tag CoIP	20818333
Intra	RAD21	O60216	SMC3	Homo sapiens	Q9UQE7	Anti Tag CoIP	28514442
Intra	RAD21	O60216	SMC3	Homo sapiens	Q9UQE7	Density Sedimentation	17112726
Intra	RAD21	O60216	SMC3	Homo sapiens	Q9UQE7	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

RAD21 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83240	Rad21 Antibody (YA2985)	WB, FC	Human, Mouse, Rat
HY-P83849	Rad21 Antibody (YA3546)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
HY-P83849A	Rad21 Antibody (YA3546)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
HY-P86621	Rad21 Antibody (YA6313)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects	Cornelia De Lange Syndrome 4 CDLS4 Cornelia De Lange Syndrome, Type 4
Mungan Syndrome	MGS Visceral Neuromyopathy, Familial, With Pseudoobstruction, Megaduodenum, Barrett Esophagus, And Cardiac Abnormalities Pseudoobstruction, Chronic Idiopathic Intestinal, With Barrett Esophagus And Cardiac Abnormalities Pseudoobstruction Chronic Idiopathic Intestinal With Barrett Esophagus And Cardiac Abnormalities Visceral Neuromyopathy Familial With Pseudoobstruction Megaduodenum Barrett Esophagus And Cardiac Abnormalities
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Cornelia De Lange Syndrome 1	De Lange Syndrome CDLS1 Cdl Cdls Typus Degenerativus Amstelodamensis Brachmann-De Lange Syndrome Bdls Amstelodamensis Typus Degenerativus Cornelia De Lange Syndrome, Type 1
Acute Megakaryoblastic Leukemia In Down Syndrome	Ds-Amkl
Intestinal Pseudo-Obstruction	Chronic Intestinal Pseudoobstruction Chronic Intestinal Pseudo-Obstruction Cipo Neuronal Intestinal Dysplasia Hollow Visceral Myopathy Familial Visceral Neuropathy Paralytic Ileus Intestinal Pseudoobstruction Chronic Idiopathic Intestinal Pseudo-Obstruction Ciip Congenital Short Bowel Syndrome Enteric Neuropathy Familial Visceral Myopathy Ipo Pseudo-Obstruction Of Intestine Pseudointestinal Obstruction Syndrome Pseudoobstructive Syndrome Congenital Idiopathic Intestinal Pseudoobstruction Visceral Myopathy, Familial
Roberts-Sc Phocomelia Syndrome	Roberts Syndrome Sc Phocomelia Syndrome RBS Long Bone Deficiencies Associated With Cleft Lip-Palate Sc Pseudothalidomide Syndrome Appelt-Gerken-Lenz Syndrome Pseudothalidomide Syndrome Tetraphocomelia-Cleft Palate Syndrome Hypomelia Hypotrichosis Facial Hemangioma Syndrome Roberts Syndrome/Sc Phocomelia Roberts Tetraphocomelia Syndrome Sc Syndrome Sc Phocomelia Sc Disease Sc Hemoglobin Sc Disease
Trichorhinophalangeal Syndrome, Type Ii	Langer-Giedion Syndrome Lgs Trichorhinophalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome Type 2 TRPS2 Monosomy 8q24.1 Chromosome 8q24.1 Deletion Syndrome Deletion 8q24.1 Giedion-Langer Syndrome Trichorhinophalangeal Dysplasia Type Ii Langer Giedion Syndrome Trps 2 Tricho-Rhino-Phalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome With Exostosis Trps Ii Tricho-Rhino-Phalangeal Syndrome 2 8q24.1 Microdeletion Syndrome 8q24.1 Deletion Syndrome
Familial Isolated Trichomegaly	Long Eyelashes Tcmgly
Barrett Esophagus	Barrett'S Esophagus Barrett Esophagus/Esophageal Adenocarcinoma Barrett Metaplasia Barrett'S Ulcer Of Esophagus Ulcerative Esophagitis Barrett'S Esophagus With Esophagitis Barrett'S Oesophagus Barretts Syndrome Barrett Syndrome BE Peptic Ulcer Of Esophagus Adenocarcinoma Of Esophagus
Ventricular Septal Defect	Ventricular Septal Defects Interventricular Septal Defect Heart Septal Defects, Ventricular Ventricular Septal Abnormality Interventricular Septum Defect Ventricular Septum Defect Vsd - [Ventricular Septum Defect] Congenital Ventricular Septal Defect Single Ventricular Septal Defect
Chronic Atrial And Intestinal Dysrhythmia	CAID Caid Syndrome Cohesinopathy Affecting Heart And Gut Rhythm Chronic Atrial Intestinal Dysrhythmia Syndrome Chronic Atrial And Intestinal Dysrhythmia Syndrome Chronic Atrial Dysrhythmia-Intestinal Motility Disorder Dysrhythmia, Atrial And Intestinal, Chronic
Kbg Syndrome	KBGS Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome
Warsaw Breakage Syndrome	WABS WBRS
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Cornelia De Lange Syndrome 3 With Or Without Midline Brain Defects	Cornelia De Lange Syndrome 3 CDLS3 Cornelia De Lange Syndrome, Type 3
Core Binding Factor Acute Myeloid Leukemia	Cbf Acute Myeloid Leukemia Cbf-Aml Core-Binding Factor Aml
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Sclerocornea	Isolated Congenital Sclerocornea
Eyelid Disease	Eyelid Diseases Eyelid Disorders
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11599	RAD21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10931F	RAD21 (356–395), biotin labeled		/	Unkown
HY-RS20093	Rad21 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26596	Rad21 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAD21	VGNC	VGNC:33680
Rattus norvegicus	RAD21	RGD	RGD:1594529
Macaca mulatta	RAD21	VGNC	VGNC:84108
Felis catus	RAD21	VGNC	VGNC:69212
Mus musculus	RAD21	MGD	MGI:108016
Canis familiaris	RAD21	VGNC	VGNC:45313
Others	RAD21	NCBI