SSU72 - SSU72 homolog, RNA polymerase II CTD phosphatase Gene

Also Known as HSPC182; PNAS-120

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29101

About SSU72

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,541,673-1,574,863 (from NCBI)

This gene has 4 transcripts (splice variants), 157 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 50.5), fat (RPKM 49.2) and 25 other tissues.

Summary

Enables RNA polymerase II CTD heptapeptide repeat Phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and mRNA polyadenylation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SSU72 Products (1)

mRNA Protein Name
NM_014188.3 NP_054907.1 RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA
IDA: Inferred from direct assay
20861839 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20818333 GOA
Biological Process GO Annotation Evidence References Source
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IMP
IMP: Inferred from mutant phenotype
20861839 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSU72 Protein Structure

Ssu72

Ssu72: Ssu72-like protein (5 - 194)

  • 0
  • 100
  • 194 a.a.
Protein Preferred Names Protein Names

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

  • CTD phosphatase SSU72

SSU72 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SSU72 Q9NP77 STAG2 Homo sapiens Q8N3U4
Anti Bait CoIP
20818333
Intra
SSU72 Q9NP77 STAG2 Homo sapiens Q8N3U4
Pull Down
20818333
Intra
SSU72 Q9NP77 RAD21 Homo sapiens O60216
Pull Down
20818333
Intra
SSU72 Q9NP77 RAD21 Homo sapiens O60216
IF
20818333
Intra
SSU72 Q9NP77 RAD21 Homo sapiens O60216
Y2H
20818333
Intra
SSU72 Q9NP77 RAD21 Homo sapiens O60216
Anti Bait CoIP
20818333
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Albinism, Oculocutaneous, Type V

  • OCA5

  • Oculocutaneous Albinism Type V

  • Oculocutaneous Albinism Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13835 SSU72 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SSU72 VGNC VGNC:77986
Rattus norvegicus SSU72 RGD RGD:1307854
Mus musculus SSU72 MGD MGI:1916241
Others SSU72 NCBI