EDTA (iron sodium)
Based on 1 Customer Validation
EDTA iron sodium (Ethylenediaminetetraacetic acid iron sodium) is an orally active food fortifier and iron chelate. EDTA iron sodium provides absorbable iron during consumption of fortified soy sauce, rice-based meals, or complementary foods made from high-phytate grains. EDTA iron sodium increases serum iron levels for up to 4 h, and total non-heme iron levels in the liver also rise with increasing doses. EDTA iron sodium is applicable to research on iron deficiency anemia and lymphoma.
For research use only. We do not sell to patients.
- CAS No.: 15708-41-5
- Formula: C10H12FeN2NaO8
- Molecular Weight:367.05
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EDTA iron sodium can be added to fish sauce and soy sauce without altering the sensory properties of the fortified condiments[1].
EDTA iron sodium exhibits dose-dependent genotoxicity both with and without metabolic activation, and its minimum effective dose ratio relative to FeSO4 is 2.2 in L5178Y mouse lymphoma cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
EDTA (iron sodium) (5.0-40.0 g/kg; p.o.; single dose) shows delayed peak serum and liver iron levels compared to other iron compounds, induces dose-dependent increases in liver nonheme iron and mortality, and has an acute oral LD50 equivalent to 1.3 g elemental Fe/kg, corresponding to a 10.0 g/kg compound dose, in young male Sprague-Dawley rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (young male)[3]
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Dosage:20.0 g/kg (time-response study); 5.0 g/kg, 10.0 g/kg, 12.5 g/kg, 15.0 g/kg, 20.0 g/kg, 30.0 g/kg, 40.0 g/kg (acute toxicity study)
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Administration:p.o.; single dose
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Result:Reached a peak serum iron level of 565 μg/dL at 2.5 hours and maintained elevation through 4 hours.
Reached a liver nonheme iron level of 90 μg/g at 4 hours after peaking at 3 hours.
Resulted in 100% survival of 8 animals, with total liver nonheme iron of 493 μg, serum iron of 430 μg/dL, and liver nonheme iron concentration of 68.8 μg/g at 5.0 g/kg.
Resulted in 50% survival of 8 animals, with total liver nonheme iron of 563 μg, serum iron of 366 μg/dL, and liver nonheme iron concentration of 97.5 μg/g at 10.0 g/kg.
Resulted in 12.5% survival of 8 animals, with total liver nonheme iron of 623 μg, serum iron of 490 μg/dL, and liver nonheme iron concentration of 157 μg/g at 12.5 g/kg.
Resulted in 0% survival of 8 animals at 15.0 g/kg.
Resulted in 12.5% survival of 8 animals at 20.0 g/kg.
Resulted in 0% survival of 4 animals at 30.0 g/kg.
Resulted in 0% survival of 6 animals at 40.0 g/kg.
Increased total liver nonheme iron with increasing dose, with a response approximately 50% lower than that observed with ferrous sulfate at equivalent elemental iron doses.
Chemical Information
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CAS No. 15708-41-5
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Appearance Solid
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Molecular Weight 367.05
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Formula C10H12FeN2NaO8
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Color Light yellow to yellow
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SMILES
[O-]C(CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O)=O.[Fe+3].[Na+]
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Synonyms
Ethylenediaminetetraacetic acid (iron sodium)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
H2O : 50 mg/mL (136.22 mM; Need ultrasonic)
DMSO : 25 mg/mL (68.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
[1]. Fidler MC, et al. Iron absorption from fish sauce and soy sauce fortified with sodium iron EDTA. Am J Clin Nutr. 2003 Aug;78(2):274-8. [Content Brief]
[2]. Davidsson L, et al. Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant: erythrocyte incorporation of iron and apparent absorption of zinc, copper, calcium, and magnesium from a complementary food based on wheat and soy in healthy infants. Am J Clin Nutr. 2005 Jan;81(1):104-9. [Content Brief]
[3]. Whittaker P, et al. Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats. Regul Toxicol Pharmacol. 2002 Dec;36(3):280-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 2.7244 mL | 13.6221 mL | 27.2442 mL | 68.1106 mL |
| 5 mM | 0.5449 mL | 2.7244 mL | 5.4488 mL | 13.6221 mL | |
| 10 mM | 0.2724 mL | 1.3622 mL | 2.7244 mL | 6.8111 mL | |
| 15 mM | 0.1816 mL | 0.9081 mL | 1.8163 mL | 4.5407 mL | |
| 20 mM | 0.1362 mL | 0.6811 mL | 1.3622 mL | 3.4055 mL | |
| 25 mM | 0.1090 mL | 0.5449 mL | 1.0898 mL | 2.7244 mL | |
| 30 mM | 0.0908 mL | 0.4541 mL | 0.9081 mL | 2.2704 mL | |
| 40 mM | 0.0681 mL | 0.3406 mL | 0.6811 mL | 1.7028 mL | |
| 50 mM | 0.0545 mL | 0.2724 mL | 0.5449 mL | 1.3622 mL | |
| 60 mM | 0.0454 mL | 0.2270 mL | 0.4541 mL | 1.1352 mL | |
| H2O | 80 mM | 0.0341 mL | 0.1703 mL | 0.3406 mL | 0.8514 mL |
| 100 mM | 0.0272 mL | 0.1362 mL | 0.2724 mL | 0.6811 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
EDTA (iron sodium) Related Classifications
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