RTRAF - RNA transcription, translation and transport factor Gene

Also Known as CLE; CLE7; hCLE; CGI99; RLLM1; hCLE1; CGI-99; LCRP369; C14orf166

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51637

About RTRAF

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:51,989,546-52,010,694 (from NCBI)

This gene has 7 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in testis (RPKM 109.7), fat (RPKM 62.2) and 25 other tissues.

Summary

Enables RNA binding activity; RNA polymerase II complex binding activity; and identical protein binding activity. Involved in negative regulation of protein kinase activity; positive regulation of transcription by RNA polymerase II; and tRNA splicing, via endonucleolytic cleavage and ligation. Located in microtubule cytoskeleton; nucleoplasm; and perinuclear region of cytoplasm. Part of tRNA-splicing Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

RTRAF Products (1)

mRNA Protein Name
NM_016039.3 NP_057123.1 RNA transcription, translation and transport factor protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
24608264 GOA
enables RNA polymerase II complex binding IDA
IDA: Inferred from direct assay
16950395 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15147888 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11507205 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
15147888 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16950395 GOA
involved in tRNA splicing, via endonucleolytic cleavage and ligation IMP
IMP: Inferred from mutant phenotype
24870230 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
15147888 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
24608264 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
15147888 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15147888 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15147888 GOA
part of tRNA-splicing ligase complex IDA
IDA: Inferred from direct assay
21311021 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTRAF Protein Structure

RLL

RLL: Putative carnitine deficiency-associated protein (1 - 244)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

RNA transcription, translation and transport factor protein

  • CLE7 homolog

RTRAF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RTRAF Q9Y224 FAM98B Homo sapiens Q52LJ0
TAP
24608264
Intra
RTRAF Q9Y224 FAM98B Homo sapiens Q52LJ0
Crosslink
30021884
Intra
RTRAF Q9Y224 FAM98A Homo sapiens Q8NCA5
Y2H Array
31515488
Intra
RTRAF Q9Y224 DDX1 Homo sapiens Q92499
Crosslink
30021884
Intra
RTRAF Q9Y224 FAM98A Homo sapiens Q8NCA5
TAP
24608264
Intra
RTRAF Q9Y224 RTRAF Homo sapiens Q9Y224
Y2H
15147888
Intra
RTRAF Q9Y224 FAM98A Homo sapiens Q8NCA5
Anti Tag CoIP
28040436
Intra
RTRAF Q9Y224 RTRAF Homo sapiens Q9Y224
GMS
24608264
Intra
RTRAF Q9Y224 DDX1 Homo sapiens Q92499
TAP
24608264
Intra
RTRAF Q9Y224 FAM98A Homo sapiens Q8NCA5
Y2H Array
25416956
Intra
RTRAF Q9Y224 RTCB Homo sapiens Q9Y3I0
Pull Down
30833792
Intra
RTRAF Q9Y224 RTRAF Homo sapiens Q9Y224
Pull Down
15147888
Intra
RTRAF Q9Y224 RTRAF Homo sapiens Q9Y224
Comig Non-Denat Gel
24608264
Intra
RTRAF Q9Y224 RTCB Homo sapiens Q9Y3I0
TAP
24608264
Intra
RTRAF Q9Y224 RTRAF Homo sapiens Q9Y224
Comigration in SDS
24608264
Intra
RTRAF Q9Y224 NIN Homo sapiens Q8N4C6
IF
15147888
Intra
RTRAF Q9Y224 NIN Homo sapiens Q8N4C6
Y2H
15147888
Intra
RTRAF Q9Y224 C2orf49 Homo sapiens Q9BVC5
Crosslink
30021884
Cross
RTRAF Q9Y224 PA Influenza A virus P31343
Pull Down
11507205
Cross
RTRAF Q9Y224 PA Influenza A virus P31343
Y2H
11507205
Cross
RTRAF Q9Y224 PA Influenza A virus Q67020
BiFC
21994455
Cross
RTRAF Q9Y224 PA Influenza A virus Q67020
Y2H
21994455
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
Central Nervous System Germinoma

  • Germinoma Of The Central Nervous System

  • Intracranial Germinoma

  • Germinoma Of Cns
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12341 RTRAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RTRAF VGNC VGNC:77087
Rattus norvegicus RTRAF RGD RGD:1304704
Mus musculus RTRAF MGD MGI:1915295
Felis catus RTRAF VGNC VGNC:103749
Bos taurus RTRAF VGNC VGNC:49536
Others RTRAF NCBI