DDX1 - DEAD-box helicase 1 Gene

Also Known as DBP-RB; UKVH5d

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1653

About DDX1

Cytogenetic location: 2p24.3 Genomic coordinates (GRCh38): 2:15,591,868-15,631,101 (from NCBI)

This gene has 24 transcripts (splice variants), 198 orthologues and 38 paralogues. Ubiquitous expression in thyroid (RPKM 36.4), brain (RPKM 36.1) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that acts as an ATP-dependent RNA helicase that has been found to promote coronaviruses replication. [provided by RefSeq, Aug 2021]

DDX1 Products (1)

mRNA	Protein	Name
NM_004939.3	NP_004930.1	ATP-dependent RNA helicase DDX1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA/RNA helicase activity	IDA IDA: Inferred from direct assay	18710941	GOA
enables RNA helicase activity	IDA IDA: Inferred from direct assay	12183465	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	19058135	GOA
enables nuclease activity	IDA IDA: Inferred from direct assay	18710941	GOA
enables poly(A) binding	IDA IDA: Inferred from direct assay	12183465	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11598190	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	19058135	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA duplex unwinding	IDA IDA: Inferred from direct assay	18710941	GOA
involved in double-strand break repair	IDA IDA: Inferred from direct assay	18710941	GOA
involved in nucleic acid metabolic process	IDA IDA: Inferred from direct assay	18710941	GOA
involved in protein localization to cytoplasmic stress granule	IMP IMP: Inferred from mutant phenotype	24965446	GOA
involved in tRNA splicing, via endonucleolytic cleavage and ligation	IMP IMP: Inferred from mutant phenotype	24870230	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cleavage body	IDA IDA: Inferred from direct assay	11598190	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24608264	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	18335541	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19058135	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA
part of tRNA-splicing ligase complex	IDA IDA: Inferred from direct assay	21311021	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX1 Protein Structure

DEAD

SPRY

Helicase_C

0
200
400
600
740 a.a.

Protein Preferred Names	Protein Names
ATP-dependent RNA helicase DDX1	DEAD (Asp-Glu-Ala-Asp) box helicase 1

DDX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DDX1	Q92499	RTRAF	Homo sapiens	Q9Y224	Anti Tag CoIP	33961781
Intra	DDX1	Q92499	RTRAF	Homo sapiens	Q9Y224	GMS	24608264
Intra	DDX1	Q92499	FAM98A	Homo sapiens	Q8NCA5	Anti Tag CoIP	33961781
Intra	DDX1	Q92499	FAM98A	Homo sapiens	Q8NCA5	Anti Tag CoIP	28040436
Cross	DDX1	Q92499	N	SARS-CoV-2	P0DTC9	Confocal	35107372

Cross: Cross-species interaction Intra: Intraspecies interaction

DDX1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84698	DDX1 Antibody (YA4395)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84698A	DDX1 Antibody (YA4395)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84699	DDX1 Antibody (YA4396)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P84699A	DDX1 Antibody (YA4396)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Bronchitis	Chronic Bronchitis Acute Bronchitis Bronchitis, Chronic Acute Bronchitis And Bronchiolitis Chest Cold Chest Infection Ci - Chest Infection Recurrent Wheezy Bronchitis Bronchitis Chronic Lower Respiratory Tract Infection Acute Lower Respiratory Tract Infection Chronic Bronchitis Nos Senile Bronchitis Bronchitis Nos In Those Under L5 Years Of Age Bronchitis Nos
Small Cell Carcinoma	Small Cell Carcinoma, Intermediate Cell Intermediate Cell Small Cell Carcinoma Small Cell Carcinoma - Intermediate Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Venezuelan Equine Encephalitis	Venezuelan Equine Fever Venezuelan Equine Encephalomyelitis Encephalitis Venezuelan Equine Encephalomyelitis, Venezuelan Equine Venezuelan Encephalitis Disorder Due To Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Virus Infection Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Heavy Chain Disease	Hcd
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Lacrimal Duct Obstruction	Blocked Lacrimal Canaliculus Obstruction Of Lacrimal Canaliculus Obstruction Of Lacrimal Ducts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116940	Sm4	Inhibitor	99.01%	Unkown
HY-RS03629	DDX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185893	UNC11676A	Inhibitor	/	Unkown
HY-187308	STK189682		/	Unkown
HY-RS17684	Ddx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24145	Ddx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DDX1	RGD	RGD:619903
Macaca mulatta	DDX1	VGNC	VGNC:71759
Mus musculus	DDX1	MGD	MGI:2144727
Canis familiaris	DDX1	VGNC	VGNC:39844
Bos taurus	DDX1	VGNC	VGNC:27955
Felis catus	DDX1	VGNC	VGNC:61396
Others	DDX1	NCBI