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Cat. No.: HY-187308

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STK189682

STK189682 is an ATPase inhibitor targeting MDA5, LGP2 and DDX1, with IC₅₀ values of 7 μM, 7 μM and 5 μM, respectively. STK189682 binds to the MDA5-ATP complex in an ATP-noncompetitive manner and does not compete with RNA.

For research use only. We do not sell to patients.

CAS No.: 765922-18-7
Formula: C₂₁H₁₆N₄O₄S₂
Molecular Weight:452.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

STK189682 Chemical Structure

CAS No.: 765922-18-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

STK189682 potently inhibits the ATPase activities of recombinant MDA5 (IC₅₀ = 7 μM), LGP2 (IC₅₀ = 7 μM) and DDX1 (IC₅₀ = 5 μM)^[1].
STK189682 is an ATP-uncompetitive inhibitor of recombinant MDA5, which is evidenced by the observation that its IC₅₀ value decreases as ATP concentration increases^[1].
STK189682 does not compete with RNA for binding to recombinant MDA5, as the IC₅₀ value remains unchanged with increasing RNA concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 765922-18-7
Molecular Weight 452.51
Formula C₂₁H₁₆N₄O₄S₂
SMILES

O=C(C1=CC=C(NC2=NC(C3=C(C)N=C(NC(C4=CC=CC=C4)=O)S3)=CS2)C=C1O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang X, et al. Identification and optimization of first-in-class RNA helicase inhibitors of DDX1, LGP2, and MDA5. European journal of medicinal chemistry. 2026 May 05;309:118724. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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