RTCB - RNA 2',3'-cyclic phosphate and 5'-OH ligase Gene

Also Known as FAAP; HSPC117; C22orf28; DJ149A16.6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51493

About RTCB

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:32,387,582-32,412,247 (from NCBI)

This gene has 6 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in duodenum (RPKM 45.6), small intestine (RPKM 40.2) and 25 other tissues.

Summary

Enables RNA Ligase (ATP) activity and vinculin binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Located in cytosol and nucleoplasm. Part of tRNA-splicing Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

RTCB Products (1)

mRNA Protein Name
NM_014306.5 NP_055121.1 RNA-splicing ligase RtcB homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA ligase (GTP) activity IDA
IDA: Inferred from direct assay
21311021 GOA
enables RNA ligase (GTP) activity IMP
IMP: Inferred from mutant phenotype
24870230 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24608264 GOA
enables vinculin binding IPI
IPI: Inferred from physical interaction
15163412 GOA
Biological Process GO Annotation Evidence References Source
involved in tRNA splicing, via endonucleolytic cleavage and ligation IDA
IDA: Inferred from direct assay
21311021 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24608264 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24608264 GOA
part of tRNA-splicing ligase complex IDA
IDA: Inferred from direct assay
21311021 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTCB Protein Structure

RtcB

RtcB: tRNA-splicing ligase RtcB (65 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

RNA-splicing ligase RtcB homolog

  • 3'-phosphate/5'-hydroxy nucleic acid ligase

RTCB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RTCB Q9Y3I0 RTRAF Homo sapiens Q9Y224
TAP
24608264
Intra
RTCB Q9Y3I0 RTRAF Homo sapiens Q9Y224
Pull Down
30833792
Intra
RTCB Q9Y3I0 RTRAF Homo sapiens Q9Y224
Anti Tag CoIP
35271311
Intra
RTCB Q9Y3I0 APPL1 Homo sapiens Q9UKG1
Y2H Array
25814554
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Oropharyngeal Anthrax
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145675A (R)-TCB2 / Unkown
HY-RS12316 RTCB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20814 Rtcb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27328 Rtcb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RTCB VGNC VGNC:34194
Macaca mulatta RTCB VGNC VGNC:77111
Mus musculus RTCB MGD MGI:106379
Felis catus RTCB VGNC VGNC:64805
Rattus norvegicus RTCB RGD RGD:1303261
Canis familiaris RTCB VGNC VGNC:49844
Others RTCB NCBI