RTCB - RNA 2',3'-cyclic phosphate and 5'-OH ligase Gene

Homo sapiens

Also known as FAAP; HSPC117; C22orf28; DJ149A16.6

Gene ID: 51493 | Gene type: protein coding

About RTCB

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:32,387,582-32,412,247 (from NCBI)

This gene has 6 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in duodenum (RPKM 45.6), small intestine (RPKM 40.2) and 25 other tissues.

Summary

Enables RNA ligase (ATP) activity and vinculin binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Located in cytosol and nucleoplasm. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

RTCB Products(1)

mRNA	Protein	Name
NM_014306.5	NP_055121.1	RNA-splicing ligase RtcB homolog

RTCB Protein Structure

RtcB

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

RNA-splicing ligase RtcB homolog

3'-phosphate/5'-hydroxy nucleic acid ligase

Related Diseases

Diseases

Alias

Oropharyngeal Anthrax

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12316	RTCB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RTCB	VGNC	VGNC:34194
Macaca mulatta	RTCB	VGNC	VGNC:77111
Mus musculus	RTCB	MGD	MGI:106379
Felis catus	RTCB	VGNC	VGNC:64805
Rattus norvegicus	RTCB	RGD	RGD:1303261
Canis familiaris	RTCB	VGNC	VGNC:49844