8α-Hydroxyhirsutinolide

Cat. No.: HY-N9699: Fiche technique Instruction de manipulation
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8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC₅₀: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea.

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8α-Hydroxyhirsutinolide Chemical Structure

CAS No. : 1394156-45-6

Size	Stock	Quantité
1 mg	Obtenir un devis 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Obtenir un devis 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Obtenir un devis
50 mg	Obtenir un devis

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Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform NF-κB:

Voir toutes les isoformes

NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Activité biologique
Pureté et documentation
Références
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	1.9 μM Compound: 2	Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay	[PMID: 22850207]
RAW264.7	IC₅₀	24.7 μM Compound: 2	Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method	[PMID: 22850207]

Masse moléculaire

296.32

Formule

C₁₅H₂₀O₆

CAS No.

1394156-45-6

SMILES

OCC1=C2/C(OC1=O)=C\[C@@]3(O[C@]([C@@H](C[C@@H]2O)C)(CC3)O)C

Structure Classification

Initial Source

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Youn UJ, et al. Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5559-62. [Content Brief]