1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Cilazapril monohydrate

Cilazapril monohydrate (Synonyms: Ro 31-2848 monohydrate)

Cat. No.: HY-A0043A Purity: 99.44%
Handling Instructions

Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.

For research use only. We do not sell to patients.

Cilazapril monohydrate Chemical Structure

Cilazapril monohydrate Chemical Structure

CAS No. : 92077-78-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 432 In-stock
Estimated Time of Arrival: December 31
100 mg USD 756 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure. Target: ACE Cilazapril is a new nonthiol group containing angiotensin converting enzyme (ACE) inhibitor. Cilazapril has been investigated in more than 4000 patients with all degrees of hypertension, as well as in the special patient groups such as the elderly, renally impaired, and patients with concomitant diseases, such as congestive cardiac failure or chronic obstructive pulmonary disease [1]. Cilazapril is a very potent and highly effective converting enzyme inhibitor. Doses well below 5 mg/day will probably suffice for therapeutic efficacy [2].

Molecular Weight

435.51

Formula

C₂₂H₃₃N₃O₆

CAS No.

92077-78-6

SMILES

O=C([[email protected]@H]1CCCN2N1C([[email protected]@H](N[[email protected]](C(OCC)=O)CCC3=CC=CC=C3)CCC2)=O)O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (229.62 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2962 mL 11.4808 mL 22.9616 mL
5 mM 0.4592 mL 2.2962 mL 4.5923 mL
10 mM 0.2296 mL 1.1481 mL 2.2962 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (6.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (6.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (6.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CilazaprilRo 31-2848Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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