1. Protein Tyrosine Kinase/RTK
  2. FGFR

FGF-401 

Cat. No.: HY-101568 Purity: >98.0%
Data Sheet SDS Handling Instructions

FGF-401 is an inhibitor of FGFR4 extracted from patent WO2015059668A1, compound example 83; has an IC50 of 1.9 nM.

For research use only. We do not sell to patients.
FGF-401 Chemical Structure

FGF-401 Chemical Structure

CAS No. : 1708971-55-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $167 In-stock
5 mg $150 In-stock
10 mg $240 In-stock
50 mg $850 In-stock
100 mg $1350 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

FGF-401 is an inhibitor of FGFR4 extracted from patent WO2015059668A1, compound example 83; has an IC50 of 1.9 nM.

IC50 & Target

IC50: 1.9 nM (FGFR4)[1]

In Vivo

FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II clinical studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma[1].

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.9741 mL 9.8705 mL 19.7410 mL
5 mM 0.3948 mL 1.9741 mL 3.9482 mL
10 mM 0.1974 mL 0.9870 mL 1.9741 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

506.56

Formula

C₂₅H₃₀N₈O₄

CAS No.

1708971-55-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 6 mg/mL (Need Ultrasonic)

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
FGF-401
Cat. No.:
HY-101568
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