1. Protein Tyrosine Kinase/RTK
  2. FGFR
  3. Roblitinib

Roblitinib (Synonyms: FGF-401)

Cat. No.: HY-101568 Purity: 99.33%
Handling Instructions

Roblitinib (FGF-401; Compound Example 83) est un inhibiteur de FGFR4 qui est hautement sélectif et puissant avec un IC50 de 1,9 nM. Roblitinib a une activité antitumorale.

Roblitinib (FGF-401; Compound Example 83) is a highly selective and potent FGFR4 inhibitor with an IC50 of 1.9 nM. Roblitinib has antitumor activity.

For research use only. We do not sell to patients.

Roblitinib Chemical Structure

Roblitinib Chemical Structure

CAS No. : 1708971-55-4

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10 mM * 1  mL in DMSO USD 201 In-stock
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50 mg USD 690 In-stock
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100 mg USD 1170 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Roblitinib (FGF-401; Compound Example 83) is a highly selective and potent FGFR4 inhibitor with an IC50 of 1.9 nM[1]. Roblitinib has antitumor activity[2].

IC50 & Target

FGFR4

1.9 nM (IC50)

In Vivo

Roblitinib (FGF-401) inhibits growth of hepatocellular cancer (HCC) and gastric cancer cell lines expressing FG19, FGFR4, and βklotho, and induces tumor regression in triple positive xenografts[2].

Clinical Trial
Molecular Weight

506.56

Formula

C₂₅H₃₀N₈O₄

CAS No.

1708971-55-4

SMILES

CN1CC(N(CC2=CC(CCCN3C(NC4=CC(NCCOC)=C(C#N)C=N4)=O)=C3N=C2C=O)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.2 mg/mL (10.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9741 mL 9.8705 mL 19.7410 mL
5 mM 0.3948 mL 1.9741 mL 3.9482 mL
10 mM 0.1974 mL 0.9870 mL 1.9741 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.33%

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Keywords:

RoblitinibFGF-401FGF401FGF 401FGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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Roblitinib
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