1. Protein Tyrosine Kinase/RTK
  2. FGFR

FGF-401 (Synonyms: roblitinib)

Cat. No.: HY-101568 Purity: 98.08%
Handling Instructions

FGF-401 is an inhibitor of FGFR4 extracted from patent WO2015059668A1, compound example 83; has an IC50 of 1.9 nM.

For research use only. We do not sell to patients.

FGF-401 Chemical Structure

FGF-401 Chemical Structure

CAS No. : 1708971-55-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 201 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 288 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1620 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

FGF-401 is an inhibitor of FGFR4 extracted from patent WO2015059668A1, compound example 83; has an IC50 of 1.9 nM.

IC50 & Target[1]

FGFR4

1.9 nM (IC50)

In Vivo

FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II clinical studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 6 mg/mL (11.84 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9741 mL 9.8705 mL 19.7410 mL
5 mM 0.3948 mL 1.9741 mL 3.9482 mL
10 mM 0.1974 mL 0.9870 mL 1.9741 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

506.56

Formula

C₂₅H₃₀N₈O₄

CAS No.

1708971-55-4

SMILES

CN1CC(N(CC2=CC(CCCN3C(NC4=CC(NCCOC)=C(C#N)C=N4)=O)=C3N=C2C=O)CC1)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
FGF-401
Cat. No.:
HY-101568
Quantity:

FGF-401

Cat. No.: HY-101568