2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Indapamide

Indapamide 

Cat. No.: HY-B0259 Purity: 99.18%
COA Handling Instructions

Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy.

For research use only. We do not sell to patients.

Indapamide Chemical Structure

Indapamide Chemical Structure

CAS No. : 26807-65-8

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
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Solid
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5 g USD 106 In-stock
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Other Forms of Indapamide:

Indapamide Related Antibodies

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Description

Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy[1][4].

In Vitro

Indapamide (0.1-500 mg/L; 20min) reduces total insulin secretory response to glucose infusions in isolated perfused rat pancreas[2].
Indapamide (1-100 μM) increases osteoblast proliferation and decreased bone resorption[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indapamide Related Antibodies
In Vivo

Indapamide (1 mg/kg/d; gastric gavage for 8 weeks) lowers blood pressure in spontaneously hypertensive rats (SHRs)[4].
Indapamide (10 mg/kg/d) decreases pressor response to oxotremorine, noradrenaline, and tyramine in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneously hypertensive rats (11 weeks)[4]
Dosage: 1 mg/kg
Administration: Gastric gavage per day for 8 weeks
Result: Decreased blood pressure by 16.9 mm Hg.
Increased the dp/dtmax, ejection fraction (EF) and fractional shortening (FS).
Clinical Trial
Molecular Weight

365.83

Appearance

Solid

Formula

C16H16ClN3O3S
CAS No.
SMILES

O=C(NN1C(C)CC2=C1C=CC=C2)C3=CC=C(Cl)C(S(=O)(N)=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (273.35 mM)

H2O : 0.67 mg/mL (1.83 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7335 mL 13.6676 mL 27.3351 mL
5 mM 0.5467 mL 2.7335 mL 5.4670 mL
10 mM 0.2734 mL 1.3668 mL 2.7335 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Indapamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Indapamide26807-65-8Potassium ChannelKcsAsulphonamidediureticagentbloodpressurevascularleftventricularhypertrophyInhibitorinhibitorinhibit

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