1. GPCR/G Protein
  2. Oxytocin Receptor

L-368,899 hydrochloride 

Cat. No.: HY-108677 Purity: 98.00%
Handling Instructions

L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent.

For research use only. We do not sell to patients.

L-368,899 hydrochloride Chemical Structure

L-368,899 hydrochloride Chemical Structure

CAS No. : 160312-62-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 247 In-stock
Estimated Time of Arrival: December 31
1 mg USD 100 In-stock
Estimated Time of Arrival: December 31
5 mg USD 190 In-stock
Estimated Time of Arrival: December 31
10 mg USD 290 In-stock
Estimated Time of Arrival: December 31
25 mg USD 590 In-stock
Estimated Time of Arrival: December 31
50 mg USD 990 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent.

IC50 & Target

IC50: 8.9 nM (rat uterus oxytocin receptor), 26 nM (human uterus oxytocin receptor)[1]

In Vitro

L-368,899 hydrochloride is a potent, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. L-368,899 is less active on vasopressin receptor in human liver and kidney, rat liver and kidney (IC50, 510 nM, 960 nM, 890 nM, 2400 nM, respectively)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6914 mL 8.4569 mL 16.9139 mL
5 mM 0.3383 mL 1.6914 mL 3.3828 mL
10 mM 0.1691 mL 0.8457 mL 1.6914 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

591.23

Formula

C₂₆H₄₃ClN₄O₅S₂

CAS No.

160312-62-9

SMILES

O=C(NC1[[email protected]@](C2(C)C)(CS(=O)(N3CCN(C4=CC=CC=C4C)CC3)=O)CC[[email protected]]2([H])C1)[[email protected]](N)CCS(=O)(C)=O.[H]Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
L-368,899 hydrochloride
Cat. No.:
HY-108677
Quantity:

L-368,899 hydrochloride

Cat. No.: HY-108677