1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. NP118809

NP118809 (Synonyms: 39-1B4)

Cat. No.: HY-14462 Purity: 98.62%
Handling Instructions

NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.

For research use only. We do not sell to patients.

NP118809 Chemical Structure

NP118809 Chemical Structure

CAS No. : 41332-24-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 106 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
200 mg USD 120 In-stock
Estimated Time of Arrival: December 31
500 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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Description

NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.

IC50 & Target[1][2]

N-Type Ca2+ Channel

0.11 μM (IC50)

L-type calcium channel

12.2 μM (IC50)

In Vitro

NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model[1]. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

460.61

Formula

C₃₂H₃₂N₂O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1710 mL 10.8552 mL 21.7103 mL
5 mM 0.4342 mL 2.1710 mL 4.3421 mL
10 mM 0.2171 mL 1.0855 mL 2.1710 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (5.43 mM); Suspended solution; Need ultrasonic and warming

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
NP118809
Cat. No.:
HY-14462
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