1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Olodaterol

Olodaterol  (Synonyms: BI1744)

Cat. No.: HY-14301 Purity: 98.48%
COA Handling Instructions

Olodaterol (BI1744) is a selective, long acting β2-adrenoceptor2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis.

For research use only. We do not sell to patients.

Olodaterol Chemical Structure

Olodaterol Chemical Structure

CAS No. : 868049-49-4

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Based on 1 publication(s) in Google Scholar

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Description

Olodaterol (BI1744) is a selective, long acting β2-adrenoceptor2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis[1][2][3].

IC50 & Target

β2 adrenoceptor

0.1 nM (EC50)

In Vitro

Olodaterol (0.001~10 nM; fibroblasts) attenuates growth factor-induced motility and proliferation[2].
Olodaterol (0.1~10 nM; fibroblasts) interferes with FGF-induced phosphorylation of signalling cascades[2].
Olodaterol (0.001~1000 nM; 30 minutes; fibroblasts) increases intracellular cAMP in a concentration-dependent manner. Olodaterol (0~10 nM; 30 minutes; fibroblasts) concentration-dependently inhibits the PICP increase with maximal efficacy of 70 % at 10 nM. Olodaterol has a subnanomolar affinity for the β2-AR (pKi=9.14) and is selective for this receptorin comparison with the β1-AR and β3-AR subtypes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Fibroblasts
Concentration: 0.1~10 nM
Incubation Time:
Result: Interfered with FGF-induced phosphorylation of signalling cascades.

Cell Proliferation Assay[2]

Cell Line: Fibroblasts
Concentration: 0.001~10 nM
Incubation Time:
Result: Attenuated growth factor-induced motility and proliferation.
In Vivo

Olodaterol (1 mg/kg; inhal.; 21 days) accelerats body weight recovery back to control levels (at day 21) and attenuats TGF-β-induced lung fibrosis[2].
Olodaterol (0.1~3 μg/kg; inhal.; 5 hours) induces a dose-dependent bronchoprotection[3].
Olodaterol (0.3 and 0.6 μg/kg; inhal.; 24 hours) induces a maximal bronchoprotection of approximately 60 % after 0.5 hours[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lung fibrosis C57BL/6 mice
Dosage: 1 mg/mL
Administration: Inhal.; 21 days
Result: Accelerated body weight recovery back to control levels (at day 21) and attenuated TGF-β-induced lung fibrosis.
Animal Model: Guinea Pigs
Dosage: 0.1~3 μg/kg
Administration: Inhal.; 5 hours
Result: Induced a dose-dependent bronchoprotection.
Animal Model: Dogs
Dosage: 0.3 and 0.6 μg/kg
Administration: Inhal.; 24 hours
Result: Olodaterol (0.6 μg/kg) induced a maximal bronchoprotection of approximately 60 % after 0.5 hours.
Clinical Trial
Molecular Weight

386.44

Formula

C21H26N2O5

CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

O=C1NC2=CC(O)=CC([C@@H](O)CNC(C)(C)CC3=CC=C(OC)C=C3)=C2OC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 6.2 mg/mL (16.04 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5877 mL 12.9386 mL 25.8772 mL
5 mM 0.5175 mL 2.5877 mL 5.1754 mL
10 mM 0.2588 mL 1.2939 mL 2.5877 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Olodaterol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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